Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | PLK1 | P53350 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.42 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.42 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.42 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | RAPGEF3 | O95398 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3555488 | 0.81 | MAPT (0.48) | KMT2ARAB9AHTTMAPTALDH1A1 | |
| SCHEMBL5545658 | 0.81 | DOT1L (0.60) | DOT1LMEN1KMT2AL3MBTL1PLK1 | |
| SCHEMBL3555862 | 0.80 | TP53 (0.50) | KMT2ARAB9AHTTMAPTALDH1A1 | |
| SCHEMBL5656080 | 0.80 | MAPT (0.50) | MEN1KMT2ARAB9AMAPTALDH1A1 | |
| SCHEMBL3552210 | 0.77 | ALDH1A1 (0.54) | MEN1KMT2ARAB9ANPC1HTT | |
| SCHEMBL5023776 | 0.76 | ALDH1A1 (0.59) | HTTMAPTALDH1A1GAASMN1; SMN2 | |
| SCHEMBL5655125 | 0.76 | RAB9A (0.52) | MEN1KMT2ARAB9ANPC1MAPT | |
| SCHEMBL5023284 | 0.75 | PRSS12 (0.43) | MEN1KMT2ARAB9AMAPTALDH1A1 | |
| SCHEMBL15619646 | 0.74 | DOT1L (0.51) | DOT1LMEN1KMT2AL3MBTL1PLK1 | |
| SCHEMBL15619322 | 0.73 | MEN1 (0.50) | DOT1LMEN1KMT2AL3MBTL1PLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7196094-B2 | Farnesyl transferase inhibiting 6-heterocyclylmethyl quinoline and quinazoline derivatives | JANSSEN PHARMACEUTICA, N.V. (BE) | 2007-03-27 | — | — | US | disclosed |
| US-20030207887-A1 | Farnesyl transferase inhibiting 6-heterocyclylmethyl quinoline and quinazoline derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 2003-11-06 | — | — | US | disclosed |
| EP-1322650-A2 | FARNESYL TRANSFERASE INHIBITING 6-HETEROCYCLYLMETHYL QUINOLINE AND QUINAZOLINE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 2003-07-02 | — | — | EP | disclosed |
| WO-2002024686-A2 | FARNESYL TRANSFERASE INHIBITING 6-HETEROCYCLYLMETHYL QUINOLINE AND QUINAZOLINE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 2002-03-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030207887-A1 | Farnesyl transferase inhibiting 6-heterocyclylmethyl quinoline and quinazoline derivatives | FNTA, FNTB, RCE1 | DOT1L 1987/4885MEN1 1318/4885KMT2A 2337/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.