Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | TOP2A | P11388 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.38 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.32 |
| ▸ | HTR6 | P50406 | 2/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 2/20 | 0.32 |
| ▸ | DRD3 | P35462 | 2/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9840423 | 0.67 | MEN1 (0.35) | ALDH1A1TOP2AKDM4ELMNAHPGD | |
| SCHEMBL10809588 | 0.66 | KDM4E (0.77) | ALDH1A1TOP2AKDM4ELMNAHPGD | |
| SCHEMBL30748678 | 0.66 | KDM4E (0.74) | ALDH1A1TOP2AKDM4ELMNAHPGD | |
| SCHEMBL9717111 | 0.66 | ALDH1A1 (0.48) | ALDH1A1TOP2AKDM4ELMNAHPGD | |
| SCHEMBL5549811 | 0.66 | KDM4E (0.74) | ALDH1A1TOP2AKDM4ELMNAHPGD | |
| SCHEMBL10809596 | 0.64 | KDM4E (0.58) | ALDH1A1TOP2AKDM4ELMNAHPGD | |
| SCHEMBL16329562 | 0.62 | TOP2A (0.55) | ALDH1A1TOP2AKDM4ELMNAHPGD | |
| SCHEMBL5546394 | 0.62 | HSP90AA1 (0.34) | ALDH1A1TOP2AKDM4ELMNAHPGD | |
| SCHEMBL2307303 | 0.62 | ADRB1 (0.50) | ALDH1A1KDM4EHSD17B10ADRB1HTR6 | |
| SCHEMBL10920987 | 0.61 | KDM4E (0.53) | ALDH1A1TOP2AKDM4ELMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1453846-B1 | 14 OR 15 MEMBERED MACROLIDES WITH ANTIBACTERIAL ACTIVITY | GLAXO GROUP LTD (GB) | 2007-05-16 | — | — | EP | disclosed |
| US-7202221-B2 | Macrolides | GLAXO GROUP LIMITED (GB) | 2007-04-10 | — | — | US | disclosed |
| US-20050080025-A1 | Macrolides | PLIVA D.D. (HR) | 2005-04-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050080025-A1 | Macrolides | IL17A, CYP51A1, IL15 | ALDH1A1 2889/4885TOP2A 2084/4885KDM4E 2733/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.