Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.35 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.34 |
| ▸ | CA3 | P07451 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12012131 | 0.80 | ALDH1A1 (0.67) | ALDH1A1TDP1KDM4EHSD17B10MAPK1 | |
| SCHEMBL21100519 | 0.78 | SLC6A4 (0.48) | ALDH1A1TDP1KDM4EHSD17B10MAPK1 | |
| SCHEMBL12581320 | 0.77 | SLC6A4 (0.53) | ALDH1A1TDP1KDM4EHSD17B10SLC6A4 | |
| SCHEMBL333951 | 0.76 | SLC6A4 (0.47) | ALDH1A1TDP1KDM4EHSD17B10TSHR | |
| SCHEMBL13923556 | 0.76 | SLC6A4 (0.47) | ALDH1A1KDM4EHSD17B10SLC6A4AR | |
| SCHEMBL15063439 | 0.74 | SLC6A4 (0.45) | ALDH1A1TDP1KDM4EHSD17B10SLC6A4 | |
| SCHEMBL7937564 | 0.74 | SLC6A4 (0.45) | ALDH1A1TDP1KDM4EHSD17B10MAPK1 | |
| SCHEMBL2480563 | 0.74 | NR1H2 (0.50) | ALDH1A1KDM4EHSD17B10CYP3A4TSHR | |
| SCHEMBL3628830 | 0.74 | ALDH1A1 (0.58) | ALDH1A1TDP1KDM4EHSD17B10MAPK1 | |
| SCHEMBL5546729 | 0.74 | SLC6A4 (0.45) | ALDH1A1TDP1KDM4EHSD17B10SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2007523865-A | — | — | 2007-08-23 | — | — | JP | claimed |
| US-7129235-B2 | Amides useful for treating pain | ABBOTT LABORATORIES (US) | 2006-10-31 | — | — | US | claimed |
| EP-1646621-A2 | NOVEL AZAHETEROCYCLIC AMIDES USEFUL FOR TREATING PAIN | Abbott Laboratories (US) | 2006-04-19 | — | — | EP | claimed |
| US-20050080095-A1 | administering a therapeuitcally effective amount of 3'-(trifluoromethyl)-N-{4-[(trifluoromethyl)sulfonyl]phenyl}-3,6-dihydro-2H-1,2'-bipyridine-4-carboxamide; antagonists of vanilloid receptor subtype I | ABBVIE INC. | 2005-04-14 | — | — | US | claimed |
| WO-2005007642-A2 | NOVEL AZAHETEROCYCLIC AMIDES USEFUL FOR TREATING PAIN | ABBOTT LABORATORIES (US) | 2005-01-27 | — | — | WO | claimed |
| EP-3163368-A1 | LIQUID CRYSTAL DISPLAY ELEMENT | JNC Corporation (JP) | 2017-05-03 | — | — | EP | disclosed |
| US-9018362-B2 | Oligonucleotide and use thereof | NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY (JP) | 2015-04-28 | — | — | US | disclosed |
| US-9018362-B2 | Oligonucleotide and use thereof | NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY (JP) | 2015-04-28 | — | — | US | disclosed |
| US-20130225797-A1 | OLIGONUCLEOTIDE AND USE THEREOF | NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY (JP) | 2013-08-29 | — | — | US | disclosed |
| US-20130225797-A1 | OLIGONUCLEOTIDE AND USE THEREOF | NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY (JP) | 2013-08-29 | — | — | US | disclosed |
| US-20120172361-A1 | TRIAZINE DERIVATIVES AND THEIR THERAPEUTICAL APPLICATIONS | CALIFORNIA CAPITAL EQUITY, LLC (US) | 2012-07-05 | — | — | US | disclosed |
| US-20120172361-A1 | TRIAZINE DERIVATIVES AND THEIR THERAPEUTICAL APPLICATIONS | CALIFORNIA CAPITAL EQUITY, LLC (US) | 2012-07-05 | — | — | US | disclosed |
| CN-1849315-A | Novel nitrogen-containing heterocyclic amides for the treatment of pain | ABBOTT LAB (US) | 2006-10-18 | — | — | CN | disclosed |
| EP-1646621-A2 | NOVEL AZAHETEROCYCLIC AMIDES USEFUL FOR TREATING PAIN | Abbott Laboratories (US) | 2006-04-19 | — | — | EP | disclosed |
| US-20050080095-A1 | administering a therapeuitcally effective amount of 3'-(trifluoromethyl)-N-{4-[(trifluoromethyl)sulfonyl]phenyl}-3,6-dihydro-2H-1,2'-bipyridine-4-carboxamide; antagonists of vanilloid receptor subtype I | ABBVIE INC. | 2005-04-14 | — | — | US | disclosed |
| WO-2005007642-A2 | NOVEL AZAHETEROCYCLIC AMIDES USEFUL FOR TREATING PAIN | ABBOTT LABORATORIES (US) | 2005-01-27 | — | — | WO | disclosed |
| US-4913728-A | HERBICIDES | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1990-04-03 | — | — | US | disclosed |
| US-4075345-A | 3-PYRIDYLMETHYL ARYL UREA RODENTICIDES COMPOSITIONS | ROHM AND HAAS COMPANY (US) | 1978-02-21 | — | — | US | disclosed |
| US-3994905-A | 3-Pyridylmethyl aryl urea rodenticides | ROHM AND HAAS COMPANY (US) | 1976-11-30 | — | — | US | disclosed |
| US-3931203-A | 3-Pyridylmethyl aryl urea rodenticides | ROHM AND HAAS COMPANY (US) | 1976-01-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120172361-A1 | TRIAZINE DERIVATIVES AND THEIR THERAPEUTICAL APPLICATIONS | CYP3A5, CYP11B2, ABCB1 | ALDH1A1 213/4885TDP1 3760/4885KDM4E 4209/4885 |
| US-20130225797-A1 | OLIGONUCLEOTIDE AND USE THEREOF | NOP2, HNRNPA2B1, NSUN2 | ALDH1A1 836/4885TDP1 1752/4885KDM4E 4572/4885 |
| US-20050080095-A1 | administering a therapeuitcally effective amount of 3'-(trifluoromethyl)-N-{4-[(trifluoromethyl)sulfonyl]phenyl}-3,6-dihydro-2H-1,2'-bipyridine-4-carboxamide; antagonists of vanilloid receptor subtype I | TRPV1, OPRL1, TRPV6 | ALDH1A1 843/4885TDP1 1724/4885KDM4E 2816/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.