Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Itopride. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 2/20 | 0.98 |
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.78 |
| ▸ | DRD3 | P35462 | 2/20 | 0.98 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.98 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.80 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.80 |
| ▸ | LMNA | P02545 | 2/20 | 0.78 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.78 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.78 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.78 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.63 |
| ▸ | PDE4A | P27815 | 2/20 | 0.58 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.58 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.58 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Itopride SCHEMBL311309 | 0.99 | DRD2 (1.00) | DRD2DRD3HRH3SMN1; SMN2MAPK1 | |
| Itopride SCHEMBL1650211 | 0.97 | DRD2 (0.96) | DRD2DRD3HRH3SMN1; SMN2MAPK1 | |
| SCHEMBL9815695 | 0.93 | DRD2 (0.88) | DRD2DRD3HRH3SMN1; SMN2MAPK1 | |
| SCHEMBL23731302 | 0.90 | DRD2 (0.84) | DRD2DRD3HRH3SMN1; SMN2MAPK1 | |
| Trimethobenzamide SCHEMBL4586216 | 0.89 | SMN1; SMN2 (1.00) | DRD2DRD3HRH3SMN1; SMN2MAPK1 | |
| Trimethobenzamide SCHEMBL41339 | 0.89 | SMN1; SMN2 (1.00) | DRD2DRD3HRH3SMN1; SMN2MAPK1 | |
| Trimethobenzamide SCHEMBL6683399 | 0.88 | DRD2 (1.00) | DRD2DRD3HRH3SMN1; SMN2MAPK1 | |
| Trimethobenzamide SCHEMBL28858 | 0.88 | DRD2 (1.00) | DRD2DRD3HRH3SMN1; SMN2MAPK1 | |
| Trimethobenzamide SCHEMBL4586062 | 0.87 | DRD2 (0.98) | DRD2DRD3HRH3SMN1; SMN2MAPK1 | |
| Trimethobenzamide SCHEMBL4586290 | 0.87 | DRD2 (0.98) | DRD2DRD3HRH3SMN1; SMN2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 579 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4416838-A1 | ELECTRONIC CIRCUIT FOR A PHOTOVOLTAIC MODULE AND METHOD FOR CONNECTING A PHOTOVOLTAIC MODULE | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. (DE) | 2024-08-21 | — | — | EP | claimed |
| CN-118384299-A | Medical organism in-vivo endoscope positioning marking liquid and preparation and application thereof | 江苏德威兰医疗器械股份有限公司 | 2024-07-26 | — | — | CN | claimed |
| CN-117843518-A | Preparation method and application of itopride hydrochloride | 迪嘉药业集团股份有限公司 | 2024-04-09 | — | — | CN | claimed |
| CN-117825573-A | Method for detecting content of hydroxylamine hydrochloride in bulk drug and application | 暨明医药科技（苏州）有限公司 | 2024-04-05 | — | — | CN | claimed |
| CN-115343380-B | Method for detecting 2-dimethylaminoethyl chloride hydrochloride in itopride hydrochloride | 珠海润都制药股份有限公司 | 2024-03-12 | — | — | CN | claimed |
| CN-116763749-A | Itopride hydrochloride pharmaceutical composition | 迪沙药业集团有限公司 | 2023-09-19 | — | — | CN | claimed |
| CN-110721151-B | Simethicone compound liquid composition and preparation method and application thereof | 远大生命科学(武汉)有限公司 | 2023-09-12 | — | — | CN | claimed |
| CN-115844847-B | Itopride hydrochloride preparation and preparation method thereof | 云南永安制药有限公司 | 2023-09-01 | — | — | CN | claimed |
| CN-115452989-B | Method for detecting itopride hydrochloride degradation impurities | 迪沙药业集团有限公司 | 2023-08-25 | — | — | CN | claimed |
| WO-2023061877-A1 | ELECTRONIC CIRCUIT FOR A PHOTOVOLTAIC MODULE AND METHOD FOR CONNECTING A PHOTOVOLTAIC MODULE | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. (DE) | 2023-04-20 | — | — | WO | claimed |
| US-20110311623-A1 | COMPOSITION FOR MANUFACTURING ORALLY DISINTEGRATING DOSAGE FORM TO PROTECT COATING LAYER OF ACTIVE SUBSTANCE | CHOONGWAE PHARMA CORPORATION (KR) | 2011-12-22 | — | — | US | claimed |
| US-20110217371-A1 | CONTROLLED-RELEASE MICROPARTICLES AND METHOD OF PREPARING SAME | AMOREPACIFIC CORPORATION (KR) | 2011-09-08 | — | — | US | claimed |
| JP-2010535196-A | — | — | 2010-11-18 | — | — | JP | claimed |
| EP-2185140-A1 | COMPOSITION FOR MANUFACTURING ORALLY DISINTEGRATING DOSAGE FORM TO PROTECT COATING LAYER OF ACTIVE SUBSTANCE | Choongwae Pharma Corporation (KR) | 2010-05-19 | — | — | EP | claimed |
| WO-2009020268-A1 | COMPOSITION FOR MANUFACTURING ORALLY DISINTEGRATING DOSAGE FORM TO PROTECT COATING LAYER OF ACTIVE SUBSTANCE | CHOONGWAE PHARMA CORPORATION (KR) | 2009-02-12 | — | — | WO | claimed |
| WO-2006134611-A1 | COMPOSITIONS OF ANTIULCERATIVE SUBSTITUTED BENZIMIDAZOLES | HETERO DRUGS LIMITED (IN) | 2006-12-21 | — | — | WO | claimed |
| WO-2006051079-A1 | PROCESS FOR PREPARING ITOPRIDE HYDROCHLORIDE | ERREGIERRE S.P.A. (IT) | 2006-05-18 | — | — | WO | claimed |
| EP-0306827-B1 | AMIDE COMPOUNDS, PROCESS FOR PREPARING THE SAME, AND COMPOSITION FOR ACTIVATING GASTRIC MOTOR FUNCTION CONTAINING THE SAME | Hokuriku Pharmaceutical Co.,Ltd (JP) | 1991-09-04 | — | — | EP | claimed |
| US-4983633-A | Amide compounds, process for preparing the same, and composition for activating gastric motor function containing the same | HOKURIKU PHARMACEUTICAL CO., LTD. (JP) | 1991-01-08 | — | — | US | claimed |
| EP-0306827-A1 | Amide compounds, process for preparing the same, and composition for activating gastric motor function containing the same | Hokuriku Pharmaceutical Co.,Ltd (JP) | 1989-03-15 | — | — | EP | claimed |