SCHEMBL5546757

SCHEMBL5546757

O=CNCCCc1ccc(OC(F)(F)C(F)(F)F)cc1

nearest known ligand 0.38

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
SLC6A5 Q9Y345 1/20 0.37
PPARA Q07869 1/20 0.35
BCHE P06276 2/20 0.35
S1PR1 P21453 2/20 0.35
S1PR3 Q99500 1/20 0.35
MEN1 O00255 1/20 0.34
KMT2A Q03164 1/20 0.34
LTA4H P09960 1/20 0.34
EPHX2 P34913 1/20 0.34
GPR84 Q9NQS5 1/20 0.34
TRPV1 Q8NER1 2/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5540659 0.91 LTA4H (0.39) SLC6A5LTA4HEPHX2GPR84TRPV1
SCHEMBL5541752 0.88 SLC6A5 (0.46) SLC6A5LTA4HEPHX2GPR84TRPV1
SCHEMBL5537500 0.84 SLC6A5 (0.47) SLC6A5LTA4HEPHX2GPR84TRPV1
SCHEMBL5545576 0.83 CHRM2 (0.44) PPARABCHEMEN1KMT2ATRPV1
SCHEMBL5547603 0.82 PPARA (0.37) SLC6A5PPARAGPR84
SCHEMBL5536584 0.81 ADH1B (0.47) BCHEEPHX2
SCHEMBL5539752 0.81 CHRM2 (0.44) PPARATRPV1
SCHEMBL5547971 0.81 PPARA (0.36) SLC6A5PPARAS1PR1S1PR3GPR84
SCHEMBL5546752 0.79 PPARA (0.35) SLC6A5PPARABCHES1PR1S1PR3
SCHEMBL3889241 0.78 EPHX2 (0.49) SLC6A5LTA4HEPHX2GPR84TRPV1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2570418-A2 2,3-dihydro-6-nitroimidazo[2,1-b]oxazoles compound OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2013-03-20 EP disclosed
EP-1555267-B1 2,3-DIHYDRO-6-NITROIMIDAZO[2,1-b]OXAZOLES OTSUKA PHARMA CO LTD (JP) 2013-01-16 EP disclosed
US-7262212-B2 2,3-dihydro-6-nitroimidazo[2,1-b]oxazoles OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2007-08-28 US disclosed
US-20060094767-A1 2,3-Dihydro-6-nitroimidazo[2,1-b]oxazoles OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2006-05-04 US disclosed
EP-1555267-A1 2,3-DIHYDRO-6-NITROIMIDAZO 2,1-b OXAZOLES OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2005-07-20 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060094767-A1 2,3-Dihydro-6-nitroimidazo[2,1-b]oxazoles NR2C2, NR4A3, NR4A2 SLC6A5 4639/4885PPARA 429/4885BCHE 4833/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.