Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA2D1 | P54289 | 12/20 | 0.69 |
| ▸ | CACNB1 | Q02641 | 12/20 | 0.69 |
| ▸ | CACNA1C | Q13936 | 4/20 | 0.69 |
| ▸ | CACNA1A | O00555 | 2/20 | 0.69 |
| ▸ | CACNA1B | Q00975 | 10/20 | 0.64 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.45 |
| ▸ | AGTR2 | P50052 | 3/20 | 0.44 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4187829 | 0.83 | CACNA2D1 (0.97) | CACNA2D1CACNB1CACNA1CCACNA1ACACNA1B | |
| SCHEMBL8239769 | 0.83 | CACNA2D1 (0.75) | CACNA2D1CACNB1CACNA1CCACNA1ACACNA1B | |
| SCHEMBL5541405 | 0.78 | CACNA2D1 (1.00) | CACNA2D1CACNB1CACNA1CCACNA1BCACNA1H | |
| SCHEMBL5269185 | 0.77 | CACNA2D1 (0.66) | CACNA2D1CACNB1CACNA1CCACNA1ACACNA1B | |
| SCHEMBL7376496 | 0.76 | ALDH1A1 (0.52) | CACNA2D1CACNB1CACNA1B | |
| SCHEMBL7376500 | 0.76 | ALDH1A1 (0.52) | CACNA2D1CACNB1CACNA1B | |
| SCHEMBL5547670 | 0.74 | CACNA2D1 (0.67) | CACNA2D1CACNB1CACNA1CCACNA1ACACNA1B | |
| SCHEMBL5268550 | 0.73 | CACNA2D1 (0.80) | CACNA2D1CACNB1CACNA1CCACNA1ACACNA1B | |
| SCHEMBL5544042 | 0.72 | CACNA2D1 (1.00) | CACNA2D1CACNB1CACNA1CCACNA1ACACNA1B | |
| SCHEMBL6507611 | 0.72 | CACNA2D1 (0.85) | CACNA2D1CACNB1CACNA1CCACNA1ACACNA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1745042-A1 | DIARYLAMINE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | Neuromed Pharmaceuticals, Ltd. (CA) | 2007-01-24 | — | — | EP | claimed |
| WO-2005097779-A1 | DIARYLAMINE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | NEUROMED PHARMACEUTICALS LTD. (CA) | 2005-10-20 | — | — | WO | claimed |