Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA2D1 | P54289 | 4/20 | 0.58 |
| ▸ | CACNB1 | Q02641 | 4/20 | 0.58 |
| ▸ | CACNA1A | O00555 | 2/20 | 0.58 |
| ▸ | CACNA1B | Q00975 | 3/20 | 0.45 |
| ▸ | CACNA1C | Q13936 | 3/20 | 0.45 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.45 |
| ▸ | CCR3 | P51677 | 2/20 | 0.45 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.45 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5547413 | 0.78 | CACNA2D1 (0.74) | CACNA2D1CACNB1CACNA1ACACNA1BCACNA1C | |
| SCHEMBL5547408 | 0.78 | CACNA2D1 (0.65) | CACNA2D1CACNB1CACNA1ACACNA1BCACNA1C | |
| SCHEMBL4189200 | 0.77 | CACNA2D1 (0.59) | CACNA2D1CACNB1CACNA1ACACNA1BCACNA1C | |
| SCHEMBL5547650 | 0.74 | CHRM2 (0.57) | CACNA2D1CACNB1CACNA1ACACNA1BCACNA1C | |
| SCHEMBL4179716 | 0.74 | CACNA2D1 (1.00) | CACNA2D1CACNB1CACNA1ACACNA1BCACNA1C | |
| SCHEMBL3426145 | 0.73 | CACNA2D1 (0.70) | CACNA2D1CACNB1CACNA1ACACNA1BCACNA1C | |
| SCHEMBL8305212 | 0.71 | CACNA2D1 (0.54) | CACNA2D1CACNB1CACNA1ACACNA1BCACNA1C | |
| SCHEMBL7493410 | 0.69 | CYP1A1 (0.48) | CACNA2D1CACNB1CACNA1AOPRK1MEN1 | |
| SCHEMBL5549077 | 0.69 | CACNA2D1 (0.58) | CACNA2D1CACNB1CACNA1BCACNA1CCACNA1G | |
| SCHEMBL5541529 | 0.68 | CACNA2D1 (0.58) | CACNA2D1CACNB1CACNA1BCACNA1CCACNA1G |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1745042-A1 | DIARYLAMINE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | Neuromed Pharmaceuticals, Ltd. (CA) | 2007-01-24 | — | — | EP | claimed |
| WO-2005097779-A1 | DIARYLAMINE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | NEUROMED PHARMACEUTICALS LTD. (CA) | 2005-10-20 | — | — | WO | claimed |