Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 2/20 | 0.57 |
| ▸ | HTR1A | P08908 | 2/20 | 0.57 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.57 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.57 |
| ▸ | DRD1 | P21728 | 2/20 | 0.57 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.57 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.57 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.57 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.57 |
| ▸ | DRD3 | P35462 | 2/20 | 0.57 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.57 |
| ▸ | BCL2 | P10415 | 1/20 | 0.57 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.57 |
| ▸ | CACNA2D1 | P54289 | 7/20 | 0.56 |
| ▸ | CACNB1 | Q02641 | 7/20 | 0.56 |
| ▸ | CACNA1B | Q00975 | 6/20 | 0.56 |
| ▸ | CACNA1C | Q13936 | 4/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5549077 | 0.88 | CACNA2D1 (0.58) | CHRM2HTR1AADRA2ACHRM1DRD1 | |
| SCHEMBL5541529 | 0.84 | CACNA2D1 (0.58) | CACNA2D1CACNB1CACNA1BCACNA1CSMN1; SMN2 | |
| SCHEMBL5547409 | 0.81 | CACNA2D1 (0.60) | CACNA2D1CACNB1CACNA1BCACNA1CSMN1; SMN2 | |
| SCHEMBL7668121 | 0.81 | CHRM2 (0.83) | CHRM2HTR1AADRA2ACHRM1DRD1 | |
| SCHEMBL7895706 | 0.79 | DRD3 (0.61) | CHRM2HTR1AADRA2ACHRM1DRD1 | |
| SCHEMBL11212785 | 0.76 | KCNH2 (0.71) | CHRM2HTR1AADRA2ACHRM1DRD1 | |
| SCHEMBL3263286 | 0.75 | CHRM2 (0.58) | CHRM2HTR1AADRA2ACHRM1DRD1 | |
| SCHEMBL5547439 | 0.74 | CACNA2D1 (0.58) | HTR1ACACNA2D1CACNB1CACNA1BCACNA1C | |
| SCHEMBL5142592 | 0.73 | CHRM2 (0.50) | CHRM2HTR1AADRA2ACHRM1DRD1 | |
| Chlorcyclizine SCHEMBL4383 | 0.73 | KCNH2 (1.00) | CHRM2HTR1AADRA2ACHRM1DRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1745042-A1 | DIARYLAMINE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | Neuromed Pharmaceuticals, Ltd. (CA) | 2007-01-24 | — | — | EP | claimed |
| WO-2005097779-A1 | DIARYLAMINE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | NEUROMED PHARMACEUTICALS LTD. (CA) | 2005-10-20 | — | — | WO | claimed |