Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.60 |
| ▸ | RAB9A | P51151 | 1/20 | 0.60 |
| ▸ | PGR | P06401 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.37 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.37 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.37 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.37 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18992826 | 0.76 | NPC1 (1.00) | NPC1RAB9APGRMEN1KMT2A | |
| SCHEMBL3540640 | 0.75 | NPC1 (0.69) | NPC1RAB9APGRMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL7105999 | 0.75 | NPC1 (0.64) | NPC1RAB9APGRMEN1KMT2A | |
| SCHEMBL3539080 | 0.74 | NPC1 (0.63) | NPC1RAB9APGRMEN1KMT2A | |
| SCHEMBL18992722 | 0.73 | NPC1 (0.69) | NPC1RAB9APGRMEN1KMT2A | |
| SCHEMBL7109388 | 0.73 | PGR (0.72) | NPC1RAB9APGRALDH1A1GRIN2D | |
| SCHEMBL8087323 | 0.72 | NPC1 (0.64) | NPC1RAB9APGRMEN1KMT2A | |
| SCHEMBL1397828 | 0.71 | NPC1 (0.60) | NPC1RAB9APGRMEN1KMT2A | |
| SCHEMBL5130200 | 0.71 | RAB9A (0.56) | NPC1RAB9APGRMEN1KMT2A | |
| SCHEMBL3455798 | 0.71 | NPC1 (0.59) | NPC1RAB9APGRMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1862181-A2 | Combination therapy using an 11B-hydroxysteroid dehydrogenase type 1 inhibitor and an antihypertensive agent for the treatment of metabolic syndrome and related diseases and disorders | NOVO NORDISK A/S (DK) | 2007-12-05 | — | — | EP | disclosed |
| EP-1854487-A2 | Combinations of an 11-beta-hydroxysteroid dehaydrogenase type 1 inhibitor and a glucocorticoid receptor agonist | Novo Nordisk A/S (DK) | 2007-11-14 | — | — | EP | disclosed |