Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA2D1 | P54289 | 13/20 | 0.60 |
| ▸ | CACNA1B | Q00975 | 13/20 | 0.60 |
| ▸ | CACNB1 | Q02641 | 13/20 | 0.60 |
| ▸ | CACNA1C | Q13936 | 5/20 | 0.60 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.56 |
| ▸ | CNR1 | P21554 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5541529 | 0.91 | CACNA2D1 (0.58) | CACNA2D1CACNA1BCACNB1CACNA1CCACNA1G | |
| SCHEMBL5547650 | 0.81 | CHRM2 (0.57) | CACNA2D1CACNA1BCACNB1CACNA1CCACNA1G | |
| SCHEMBL5549077 | 0.81 | CACNA2D1 (0.58) | CACNA2D1CACNA1BCACNB1CACNA1CCACNA1G | |
| SCHEMBL5547406 | 0.75 | CACNA2D1 (1.00) | CACNA2D1CACNA1BCACNB1CACNA1CCACNA1G | |
| SCHEMBL5544039 | 0.75 | CACNA2D1 (1.00) | CACNA2D1CACNA1BCACNB1CACNA1CCACNA1G | |
| SCHEMBL4207187 | 0.74 | CACNA2D1 (0.72) | CACNA2D1CACNA1BCACNB1CACNA1CCACNA1G | |
| SCHEMBL4243353 | 0.73 | OPRM1 (0.68) | CACNA2D1CACNA1BCACNB1CACNA1CCACNA1G | |
| SCHEMBL5267980 | 0.71 | CACNA2D1 (1.00) | CACNA2D1CACNA1BCACNB1CACNA1CCACNA1G | |
| SCHEMBL3397448 | 0.71 | CACNA2D1 (1.00) | CACNA2D1CACNA1BCACNB1CACNA1CCACNA1G | |
| SCHEMBL8620125 | 0.67 | CACNA2D1 (0.63) | CACNA2D1CACNA1BCACNB1CACNA1CCACNA1G |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1745042-A1 | DIARYLAMINE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | Neuromed Pharmaceuticals, Ltd. (CA) | 2007-01-24 | — | — | EP | claimed |
| WO-2005097779-A1 | DIARYLAMINE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | NEUROMED PHARMACEUTICALS LTD. (CA) | 2005-10-20 | — | — | WO | claimed |
| EP-1745042-A1 | DIARYLAMINE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | Neuromed Pharmaceuticals, Ltd. (CA) | 2007-01-24 | — | — | EP | disclosed |
| WO-2005097779-A1 | DIARYLAMINE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | NEUROMED PHARMACEUTICALS LTD. (CA) | 2005-10-20 | — | — | WO | disclosed |