Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.55 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | ESR1 | P03372 | 2/20 | 0.47 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | TTR | P02766 | 1/20 | 0.47 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.43 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.41 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 2/20 | 0.41 |
| ▸ | MAOB | P27338 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5541364 | 0.85 | TDP1 (0.60) | BRD4CREBBPALDH1A1CYP3A4MAPT | |
| SCHEMBL9749055 | 0.81 | ESR1 (0.61) | ESR1ESR2CHRNA7 | |
| SCHEMBL9749565 | 0.81 | KDM4E (0.47) | BRD4CREBBPALDH1A1KDM4ECYP3A4 | |
| SCHEMBL7916564 | 0.78 | CREBBP (0.50) | BRD4CREBBPALDH1A1KDM4ETDP1 | |
| SCHEMBL21657656 | 0.78 | CREBBP (0.50) | BRD4CREBBPALDH1A1KDM4ETDP1 | |
| SCHEMBL13799419 | 0.77 | AKR1B1 (0.44) | BRD4CREBBPALDH1A1KDM4ETDP1 | |
| SCHEMBL16372547 | 0.77 | TDP1 (0.44) | BRD4CREBBPALDH1A1KDM4EMAPT | |
| SCHEMBL18536396 | 0.77 | AKR1B1 (0.44) | ALDH1A1KDM4ETDP1MAOBGAA | |
| SCHEMBL5547658 | 0.77 | ALDH1A1 (0.47) | BRD4CREBBPALDH1A1KDM4EMAPT | |
| SCHEMBL18114486 | 0.77 | PBRM1 (0.56) | ALDH1A1KDM4EMAPTTDP1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2570418-A2 | 2,3-dihydro-6-nitroimidazo[2,1-b]oxazoles compound | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2013-03-20 | — | — | EP | disclosed |
| EP-1555267-B1 | 2,3-DIHYDRO-6-NITROIMIDAZO[2,1-b]OXAZOLES | OTSUKA PHARMA CO LTD (JP) | 2013-01-16 | — | — | EP | disclosed |
| US-7923457-B2 | Quinoline derivatives | AGOURON PHARMACEUTICALS INC. (US) | 2011-04-12 | — | — | US | disclosed |
| US-20090069316-A1 | NOVEL QUINOLINE DERIVATIVES | AGOURON PHARMACEUTICALS, INC. | 2009-03-12 | — | — | US | disclosed |
| US-7262212-B2 | 2,3-dihydro-6-nitroimidazo[2,1-b]oxazoles | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2007-08-28 | — | — | US | disclosed |
| US-7157470-B2 | Sulfonylaminovalerolactams and derivatives thereof as factor Xa inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-01-02 | — | — | US | disclosed |
| US-20060094767-A1 | 2,3-Dihydro-6-nitroimidazo[2,1-b]oxazoles | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2006-05-04 | — | — | US | disclosed |
| EP-1555267-A1 | 2,3-DIHYDRO-6-NITROIMIDAZO 2,1-b OXAZOLES | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2005-07-20 | — | — | EP | disclosed |
| EP-0333498-B1 | Process for preparation of a gelled polyester for toner | MITSUBISHI RAYON CO (JP) | 1997-07-16 | — | — | EP | disclosed |
| US-5368968-A | Modified polyester resins, a process for their preparation and toners containing such polyester resins | BAYER AKTIENGESELLSCHAFT (DE) | 1994-11-29 | — | — | US | disclosed |
| US-4980448-A | OFFSET AND BLOCKING RESISTANCE; SELF-CHARGING; SHARP COPIED IMAGES | MITSUBISHI RAYON COMPANY, LTD. (JP) | 1990-12-25 | — | — | US | disclosed |
| EP-0333498-A2 | Process for preparation of a gelled polyester for toner | MITSUBISHI RAYON CO., LTD. (JP) | 1989-09-20 | — | — | EP | disclosed |
| US-4002647-A | INSECTICIDES | HOFFMANN-LA ROCHE INC. (US) | 1977-01-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090069316-A1 | NOVEL QUINOLINE DERIVATIVES | COQ8B, COQ8A, MCM5 | BRD4 180/4885CREBBP 1323/4885ALDH1A1 2332/4885 |
| US-20060094767-A1 | 2,3-Dihydro-6-nitroimidazo[2,1-b]oxazoles | NR2C2, NR4A3, NR4A2 | BRD4 1012/4885CREBBP 1702/4885ALDH1A1 355/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.