Sugi Predict

Sugi Predict / Targets / COQ8B

COQ8B

Atypical kinase COQ8B, mitochondrial · Q96D53 · COQ8B on Sugi Atlas →

978 patent compounds predicted against COQ8B, 882 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL4135600 SCHEMBL4135600 0.78 2/20
SCHEMBL2650684 SCHEMBL2650684 0.75 2/20
SCHEMBL6465326 SCHEMBL6465326 0.74 2/20
SCHEMBL4553131 SCHEMBL4553131 0.70 2/20
SCHEMBL7231228 SCHEMBL7231228 0.70 2/20
SCHEMBL2648503 SCHEMBL2648503 0.70 2/20
SCHEMBL2649542 SCHEMBL2649542 0.70 2/20
SCHEMBL4551864 SCHEMBL4551864 0.70 2/20
SCHEMBL7249555 SCHEMBL7249555 0.70 2/20
SCHEMBL2649978 SCHEMBL2649978 0.66 2/20
SCHEMBL2650680 SCHEMBL2650680 0.66 2/20
SCHEMBL13497841 SCHEMBL13497841 0.65 2/20
SCHEMBL4553479 SCHEMBL4553479 0.63 2/20
SCHEMBL8486792 SCHEMBL8486792 0.62 2/20
SCHEMBL4569577 SCHEMBL4569577 0.62 2/20
SCHEMBL9196324 SCHEMBL9196324 0.61 2/20
SCHEMBL7228886 SCHEMBL7228886 0.61 2/20
SCHEMBL69095 SCHEMBL69095 0.60 2/20
SCHEMBL8490670 SCHEMBL8490670 0.60 2/20
SCHEMBL7989834 SCHEMBL7989834 0.60 2/20

Clinical trials — most relevant to COQ8B by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Phase III Trial of Coenzyme Q10 in Mitochondrial Disease PHASE3COMPLETED
A Study of the Efficacy and Safety of MT1621 in Thymidine Kinase 2 (TK2) Deficiency (Treatment naïve) PHASE3WITHDRAWN
Clinical Evaluation of the Effect of Metformin in Sepsis PHASE3UNKNOWN
A Study of Bezafibrate in Mitochondrial Myopathy PHASE2COMPLETED
Mitochondrial Dysfunction in the Pathophysiology and Treatment of Bipolar Disorder PHASE2WITHDRAWN
Prevent Cardiac Surgery Associated AKI Trial PHASE2RECRUITING
Nicotinamide Riboside on Mitochondrial Function in Li-Fraumeni Syndrome PHASE1/PHASE2COMPLETED
Ubiquinol in Parkinson's Disease: Safety, Tolerability, and Effects Upon Oxidative Damage and Mitochondrial Biomarkers PHASE2COMPLETED
Does Clinical Treatment of Mitochondrial Dysfunction Impact Autism Spectrum Disorder (ASD)? PHASE1UNKNOWN
Tissue Sample Study for Mitochondrial Disorders nanENROLLING_BY_INVITATION
Genomic Profiling of Mitochondrial Disease - Imaging Analysis for Precise Mitochondrial Medicine nanCOMPLETED
The Natural History of Mitochondrial Diseases nanRECRUITING
Evaluation of Ubiquinol on Mitochondrial Oxidative Capacity in Statin Patients Using 31PMRS nanCOMPLETED
Nicotinamide Riboside and Mitochondrial Biogenesis nanCOMPLETED
Exercise Training Effects on Muscle Function in Adults With Mitochondrial Myopathy nanRECRUITING
MITOMICS : a Multi-OMICS Approach for the Diagnosis of Mitochondrial Diseases nanRECRUITING
The Genetics of Diabetes in Southern California Chinese Americans nanWITHDRAWN
Human Mitochondrial Stress-driven Obesity Resistance nanCOMPLETED
Combined Effects of Statins and Exercise on Training Sensitive Health Markers nanCOMPLETED
Assessing the Role of Mitochondrial Dysfunction in Primary Progressive Multiple Sclerosis nanUNKNOWN
North American Mitochondrial Disease Consortium Patient Registry and Biorepository (NAMDC) nanRECRUITING
Effect of Subtle Energy Transmission and Tao Calligraphy Mindfulness Practice on Mitochondrial DNA in Peripheral Blood Leukocytes nanNOT_YET_RECRUITING
Identification of Large-Scale Mutations of POLG Gene by QMPSF in Patients With Mitochondrial DNA Instability. nanUNKNOWN
Clinical Study of Hydroxytyrosol (HT) in Mitochondrial Diseases nanCOMPLETED
Gastrointestinal Dysfunction in Children Affected With Mitochondrial Disorders nanCOMPLETED
Relationship Between Mitochondrial Dysfunction and Fatique in Cancer Patients Following External Beam Radiation Therapy nanCOMPLETED
Independent and Additive Effects Of Micronutrients With Metformin In Patients With PCOS nanCOMPLETED
Polycystic Ovary Syndrome, Mitochondrial Dysfunction, Obesity, Insulin Resistance Infertility (POMODORI) Cohort nanRECRUITING
Identification of New Candidate Genes in Patients With Mitochondrial Disease by High Resolution Chromosome Analysis on DNA Chip nanCOMPLETED
Pharmacokinetic Study on Three Formulations of Coenzyme Q10 With Different Carriers nanUNKNOWN

Related proteins — ESM-2 sequence neighbours (a COQ8B binder may also engage these)

ProteinNameSimilarity
Q6AY19 — 0.999 Q6AY19 →
Q566J8 — 0.994 Q566J8 →
Q5BJQ0 — 0.987 Q5BJQ0 →
Q60936 — 0.980 Q60936 →
A3QJU3 — 0.980 A3QJU3 →
COQ8A Atypical kinase COQ8A, mitochondrial 0.979 landscape →
ADCK5 Uncharacterized aarF domain-containing protein kinase 5 0.978 landscape →
Q91W34 — 0.978 Q91W34 →
Q5RGU1 — 0.976 Q5RGU1 →
Q8N490 — 0.976 Q8N490 →
Q29RI0 — 0.976 Q29RI0 →
TARS2 Threonine--tRNA ligase, mitochondrial 0.976 landscape →
Q8CGK3 — 0.975 Q8CGK3 →
Q5JTZ9 — 0.975 Q5JTZ9 →
Q8VDP3 — 0.975 Q8VDP3 →
P22570 — 0.975 P22570 →
Q5R8F6 — 0.975 Q5R8F6 →
Q9ES38 — 0.974 Q9ES38 →
Q8TDZ2 — 0.973 Q8TDZ2 →
Q9QX60 — 0.973 Q9QX60 →
A7YY46 — 0.973 A7YY46 →
D3ZX08 — 0.973 D3ZX08 →
P22557 — 0.973 P22557 →
Q80V03 — 0.973 Q80V03 →
D3ZBP4 — 0.972 D3ZBP4 →
SCO2 Protein SCO2 homolog, mitochondrial 0.972 landscape →
Q3SYT1 — 0.972 Q3SYT1 →
Q8K370 — 0.972 Q8K370 →
Q59HJ6 — 0.972 Q59HJ6 →
Q3UHX9 — 0.972 Q3UHX9 →