Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNM1 | Q05193 | 12/20 | 0.94 |
| ▸ | HTT | P42858 | 2/20 | 0.94 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.79 |
| ▸ | RAD52 | P43351 | 2/20 | 0.79 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.67 |
| ▸ | TP53 | P04637 | 1/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.67 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.67 |
| ▸ | TSHR | P16473 | 1/20 | 0.67 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.67 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.67 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.64 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL8894051 | 1.00 | DNM1 (0.94) | DNM1HTTHSP90AA1RAD52KMT2A | |
| Bromide SCHEMBL366842 | 1.00 | DNM1 (0.94) | DNM1HTTHSP90AA1RAD52KMT2A | |
| Bromide SCHEMBL5088590 | 1.00 | DNM1 (0.94) | DNM1HTTHSP90AA1RAD52KMT2A | |
| Bromide SCHEMBL668957 | 1.00 | DNM1 (0.94) | DNM1HTTHSP90AA1RAD52KMT2A | |
| Bromide SCHEMBL1318093 | 1.00 | DNM1 (0.94) | DNM1HTTHSP90AA1RAD52KMT2A | |
| Bromide SCHEMBL9179827 | 1.00 | DNM1 (0.94) | DNM1HTTHSP90AA1RAD52KMT2A | |
| Bromide SCHEMBL22397860 | 1.00 | DNM1 (0.94) | DNM1HTTHSP90AA1RAD52KMT2A | |
| Bromide SCHEMBL22397869 | 1.00 | DNM1 (0.94) | DNM1HTTHSP90AA1RAD52KMT2A | |
| Bromide SCHEMBL21986903 | 1.00 | DNM1 (0.94) | DNM1HTTHSP90AA1RAD52KMT2A | |
| Bromide SCHEMBL9172996 | 1.00 | DNM1 (0.94) | DNM1HTTHSP90AA1RAD52KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7169499-B2 | Sulfonated polyphosphazenes, uses thereof, and methods for preparing same | PARALLEL SOLUTIONS, INC. (US) | 2007-01-30 | — | — | US | disclosed |
| EP-1551904-A4 | SULFONATED POLYPHOSPHAZENES, USES THEREOF, AND METHODS FOR PREPARING SAME | PARALLEL SOLUTIONS INC (US) | 2006-04-05 | — | — | EP | disclosed |
| EP-1551904-A1 | SULFONATED POLYPHOSPHAZENES, USES THEREOF, AND METHODS FOR PREPARING SAME | Parallel Solutions, Inc. (US) | 2005-07-13 | — | — | EP | disclosed |
| US-20040033406-A1 | Sulfonated polyphosphazenes, uses thereof, and methods for preparing same | INNOVO BIOPOLYMERS, LLC | 2004-02-19 | — | — | US | disclosed |
| WO-2003102050-A1 | SULFONATED POLYPHOSPHAZENES, USES THEREOF, AND METHODS FOR PREPARING SAME | PARALLEL SOLUTIONS, INC. (US) | 2003-12-11 | — | — | WO | disclosed |