Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR2 | P50052 | 2/20 | 0.67 |
| ▸ | PPARG | P37231 | 3/20 | 0.41 |
| ▸ | AGTR1 | P30556 | 4/20 | 0.41 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.38 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.38 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL683371 | 0.93 | AGTR2 (0.78) | AGTR2PPARGAGTR1 | |
| SCHEMBL2927273 | 0.92 | AGTR2 (0.77) | AGTR2PPARGAGTR1 | |
| Potassium SCHEMBL3033376 | 0.92 | AGTR2 (0.77) | AGTR2PPARGAGTR1 | |
| SCHEMBL15456840 | 0.88 | AGTR2 (0.87) | AGTR2PPARGAGTR1ABCC3ABCC4 | |
| Potassium SCHEMBL3757615 | 0.87 | AGTR2 (0.86) | AGTR2PPARGAGTR1ABCC3ABCC4 | |
| SCHEMBL3757603 | 0.87 | AGTR2 (0.86) | AGTR2PPARGAGTR1ABCC3ABCC4 | |
| SCHEMBL1380674 | 0.85 | PPARG (0.46) | AGTR2PPARGAGTR1 | |
| SCHEMBL15702902 | 0.84 | AGTR2 (0.83) | AGTR2PPARGAGTR1ABCC3ABCC4 | |
| SCHEMBL2132264 | 0.83 | AGTR2 (0.63) | AGTR2AGTR1ABCC3ABCC4ABCB11 | |
| SCHEMBL683639 | 0.82 | AGTR2 (0.65) | AGTR2PPARGAGTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1863801-A2 | BENZIMIDAZOLE DERIVATIVE AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2007-12-12 | — | — | EP | disclosed |
| WO-2006107062-A2 | BENZIMIDAZOLE DERIVATIVE AND USE AS ANGIOTENSIN II ANTAGONIST | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2006-10-12 | — | — | WO | disclosed |