Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.47 |
| ▸ | RAD52 | P43351 | 1/20 | 0.47 |
| ▸ | GPR18 | Q14330 | 7/20 | 0.47 |
| ▸ | GBA1 | P04062 | 1/20 | 0.47 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | HTR6 | P50406 | 2/20 | 0.45 |
| ▸ | ILK | Q13418 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | PAK4 | O96013 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5545434 | 0.84 | GPR18 (0.46) | KMT2APOLBSLC2A1RAD52GPR18 | |
| SCHEMBL5355790 | 0.72 | ADORA1 (0.53) | KMT2APOLBSLC2A1RAD52GPR18 | |
| SCHEMBL5354834 | 0.72 | ADORA1 (0.53) | KMT2APOLBSLC2A1RAD52GPR18 | |
| SCHEMBL5545544 | 0.72 | TRPM8 (0.49) | KMT2APOLBMEN1MAPT | |
| SCHEMBL21248401 | 0.70 | GBA1 (0.45) | KMT2APOLBSLC2A1RAD52GPR18 | |
| SCHEMBL3524781 | 0.70 | CLK4 (0.45) | KMT2ALMNASMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL21248476 | 0.70 | GBA1 (0.44) | KMT2APOLBSLC2A1RAD52GPR18 | |
| SCHEMBL5549374 | 0.70 | METAP1 (0.42) | NPC1RAB9ADRD2 | |
| SCHEMBL21092866 | 0.69 | GBA1 (0.44) | KMT2APOLBSLC2A1RAD52GPR18 | |
| SCHEMBL21093186 | 0.69 | GBA1 (0.43) | KMT2APOLBSLC2A1RAD52GPR18 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678180-B1 | SUBSTITUTED 2H-[1,2,4]TRIAZOLO 4,3-A PYRAZINES AS GSK-3 INHIBITORS | PFIZER PROD INC (US) | 2007-08-08 | — | — | EP | disclosed |