Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 3/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | HTR1D | P28221 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | LTA4H | P09960 | 5/20 | 0.46 |
| ▸ | PLA2G2A | P14555 | 5/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.45 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.44 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5545434 | 0.84 | GPR18 (0.46) | POLBKDM4EMAPTMEN1KMT2A | |
| SCHEMBL5543567 | 0.75 | ADORA1 (0.47) | — | |
| SCHEMBL5545429 | 0.74 | GSK3B (0.46) | MAPT | |
| SCHEMBL5548494 | 0.72 | KMT2A (0.47) | POLBMAPTMEN1KMT2A | |
| SCHEMBL10651750 | 0.71 | POLB (0.73) | TRPM8POLBHTR1DKDM4EMAPT | |
| SCHEMBL5548616 | 0.71 | CA12 (0.40) | POLBKDM4E | |
| SCHEMBL5548595 | 0.71 | GSK3B (0.48) | KDM4E | |
| SCHEMBL5549261 | 0.71 | KMT2A (0.48) | POLBKDM4EMAPTMEN1KMT2A | |
| SCHEMBL10748382 | 0.70 | POLB (0.58) | TRPM8POLBHTR1DKDM4EMAPT | |
| SCHEMBL5549402 | 0.70 | ADORA1 (0.43) | MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678180-B1 | SUBSTITUTED 2H-[1,2,4]TRIAZOLO 4,3-A PYRAZINES AS GSK-3 INHIBITORS | PFIZER PROD INC (US) | 2007-08-08 | — | — | EP | disclosed |