Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 6/20 | 0.39 |
| ▸ | GSK3A | P49840 | 5/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CRHBP | P24387 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5549283 | 0.81 | GSK3B (0.58) | GSK3BGSK3AADORA1KDM4E | |
| SCHEMBL3529299 | 0.81 | GSK3B (0.41) | GSK3BGSK3AADORA1 | |
| SCHEMBL5549261 | 0.81 | KMT2A (0.48) | GAAKDM4ESMN1; SMN2POLBTSHR | |
| SCHEMBL5545429 | 0.81 | GSK3B (0.46) | GSK3BGSK3AADORA1LMNA | |
| SCHEMBL5543514 | 0.79 | GSK3B (0.40) | GSK3BGSK3AADORA1KDM4ESMN1; SMN2 | |
| SCHEMBL5549416 | 0.78 | PDE5A (0.40) | GSK3BGSK3AGAAKDM4ESMN1; SMN2 | |
| SCHEMBL3527695 | 0.77 | GSK3B (0.42) | GSK3BGSK3AADORA1POLBTSHR | |
| SCHEMBL5545434 | 0.77 | GPR18 (0.46) | KDM4ESMN1; SMN2ALDH1A1POLBMAPK1 | |
| SCHEMBL5543318 | 0.77 | MEN1 (0.40) | GSK3BGSK3AADORA1 | |
| SCHEMBL3528033 | 0.77 | GSK3B (0.56) | GSK3BGSK3AADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678180-B1 | SUBSTITUTED 2H-[1,2,4]TRIAZOLO 4,3-A PYRAZINES AS GSK-3 INHIBITORS | PFIZER PROD INC (US) | 2007-08-08 | — | — | EP | disclosed |