⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9132154 | 0.86 | FDPS (0.39) | — | |
| SCHEMBL8671012 | 0.85 | FDPS (0.47) | — | |
| SCHEMBL345097 | 0.80 | — | — | |
| Hydrochloric Acid SCHEMBL1121573 | 0.78 | — | — | |
| SCHEMBL5871559 | 0.76 | — | — | |
| SCHEMBL357852 | 0.76 | — | — | |
| Ethane SCHEMBL28789069 | 0.76 | — | — | |
| SCHEMBL257550 | 0.76 | — | — | |
| SCHEMBL1680371 | 0.76 | — | — | |
| SCHEMBL841789 | 0.76 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0364350-B1 | 4-Methyl-5[2-(4-phenyl-1-piperazinyl)-ethyl] thiazole derivatives, their preparation and pharmaceutical compositions containing them | INST RECH CHIM BIOLOG (FR) | 1994-01-12 | — | — | EP | claimed |
| WO-1990003972-A1 | DERIVATIVES OF METAL-4 ((PHENYL-4 PIPERAZINYL-1)-2 ETHYL))-5 THIAZOLE | INSTITUT DE RECHERCHES CHIMIQUES ET BIOLOGIQUES APPLIQUEES (I.R.C.E.B.A.) (FR) | 1990-04-19 | — | — | WO | claimed |
| EP-0364350-A1 | 4-Methyl-5[2-(4-phenyl-1-piperazinyl)-ethyl] thiazole derivatives, their preparation and pharmaceutical compositions containing them | INSTITUT DE RECHERCHES CHIMIQUES ET BIOLOGIQUES APPLIQUEES (IRCEBA) (FR) | 1990-04-18 | — | — | EP | claimed |
| WO-2018166528-A1 | PYRIMIDINYL-PYRIDYLOXY-NAPHTHYL COMPOUNDS AND METHODS OF TREATING IRE1-RELATED DISEASES AND DISORDERS | GENENTECH, INC. (US) | 2018-09-20 | — | — | WO | disclosed |
| EP-1785134-A2 | Thiazole, imidazole and oxazole compounds and treatments of disorders associated with protein aging | ALTEON, INC. (US) | 2007-05-16 | — | — | EP | disclosed |
| US-20060014781-A1 | Thiazole, imidazole and oxazole compounds and treatments of disorders associated with protein aging | SYNVISTA THERAPEUTICS, INC. | 2006-01-19 | — | — | US | disclosed |
| US-6960605-B2 | Thiazole, imidazole and oxazole compounds and treatments of disorders associated with protein aging | ALTEON, INC. (US) | 2005-11-01 | — | — | US | disclosed |
| WO-2005097093-A1 | SLEEP INDUCING COMPOUNDS AND METHODS RELATING THERETO | NEUROCRINE BIOSCIENCES, INC. (US) | 2005-10-20 | — | — | WO | disclosed |
| EP-1248615-A4 | THIAZOLE, IMIDAZOLE AND OXAZOLE COMPOUNDS AND TREATMENTS OF DISORDERS ASSOCIATED WITH PROTEIN AGING | ALTEON INC (US) | 2004-08-04 | — | — | EP | disclosed |
| CN-1426303-A | Thiazole, imidazole and oxazole compounds and treatment of diseases associated with protein aging | ALTEON INC (US) | 2003-06-25 | — | — | CN | disclosed |
| EP-1248615-A1 | THIAZOLE, IMIDAZOLE AND OXAZOLE COMPOUNDS AND TREATMENTS OF DISORDERS ASSOCIATED WITH PROTEIN AGING | Alteon, Inc. (US) | 2002-10-16 | — | — | EP | disclosed |
| US-20020022622-A1 | Thiazole, imidazole and oxazole compounds and treatments of disorders associated with protein aging | SYNVISTA THERAPEUTICS, INC. | 2002-02-21 | — | — | US | disclosed |
| WO-2001052847-A1 | THIAZOLE, IMIDAZOLE AND OXAZOLE COMPOUNDS AND TREATMENTS OF DISORDERS ASSOCIATED WITH PROTEIN AGING | ALTEON, INC. (US) | 2001-07-26 | — | — | WO | disclosed |
| EP-0364350-B1 | 4-Methyl-5[2-(4-phenyl-1-piperazinyl)-ethyl] thiazole derivatives, their preparation and pharmaceutical compositions containing them | INST RECH CHIM BIOLOG (FR) | 1994-01-12 | — | — | EP | disclosed |
| WO-1990003972-A1 | DERIVATIVES OF METAL-4 ((PHENYL-4 PIPERAZINYL-1)-2 ETHYL))-5 THIAZOLE | INSTITUT DE RECHERCHES CHIMIQUES ET BIOLOGIQUES APPLIQUEES (I.R.C.E.B.A.) (FR) | 1990-04-19 | — | — | WO | disclosed |
| EP-0364350-A1 | 4-Methyl-5[2-(4-phenyl-1-piperazinyl)-ethyl] thiazole derivatives, their preparation and pharmaceutical compositions containing them | INSTITUT DE RECHERCHES CHIMIQUES ET BIOLOGIQUES APPLIQUEES (IRCEBA) (FR) | 1990-04-18 | — | — | EP | disclosed |