Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 5/20 | 0.38 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.38 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5549030 | 0.83 | THRB (0.40) | ADORA1ALDH1A1LMNAMAPTMEN1 | |
| SCHEMBL3528837 | 0.79 | GSK3B (0.47) | ADORA1 | |
| SCHEMBL3523080 | 0.78 | GSK3A (0.50) | ADORA1ALDH1A1LMNAMAPTMEN1 | |
| SCHEMBL5549007 | 0.78 | KMT2A (0.51) | ALDH1A1LMNAMAPTMEN1KMT2A | |
| SCHEMBL5543068 | 0.78 | SMN1; SMN2 (0.41) | ADORA1ALDH1A1LMNAMAPTMEN1 | |
| SCHEMBL5545434 | 0.77 | GPR18 (0.46) | ALDH1A1LMNAMAPTMEN1KMT2A | |
| SCHEMBL5545643 | 0.77 | GSK3B (0.34) | ADORA1 | |
| SCHEMBL5550039 | 0.77 | GSK3A (0.46) | ADORA1LMNAMAPTMEN1KMT2A | |
| SCHEMBL5545556 | 0.76 | GSK3A (0.48) | ADORA1 | |
| SCHEMBL5543587 | 0.76 | GSK3B (0.39) | ADORA1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678180-B1 | SUBSTITUTED 2H-[1,2,4]TRIAZOLO 4,3-A PYRAZINES AS GSK-3 INHIBITORS | PFIZER PROD INC (US) | 2007-08-08 | — | — | EP | disclosed |