Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HCN4 | Q9Y3Q4 | 1/20 | 0.39 |
| ▸ | CRHBP | P24387 | 2/20 | 0.39 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5545548 | 0.92 | MEN1 (0.36) | MAPTNPSR1LMNATP53TDP1 | |
| SCHEMBL5543751 | 0.79 | LMNA (0.39) | LMNAL3MBTL1POLB | |
| SCHEMBL5549410 | 0.79 | TLR9 (0.43) | NPSR1LMNAPOLB | |
| SCHEMBL3526664 | 0.77 | GAA (0.45) | MAPTNPSR1LMNATP53TDP1 | |
| SCHEMBL5545643 | 0.75 | GSK3B (0.34) | — | |
| SCHEMBL5548887 | 0.74 | KAT2B (0.40) | MAPTNPSR1 | |
| SCHEMBL5548609 | 0.73 | MAPK1 (0.37) | — | |
| SCHEMBL5549388 | 0.73 | IRAK4 (0.33) | — | |
| SCHEMBL5549838 | 0.73 | PGK1 (0.40) | L3MBTL1 | |
| SCHEMBL5545590 | 0.71 | GSK3B (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678180-B1 | SUBSTITUTED 2H-[1,2,4]TRIAZOLO 4,3-A PYRAZINES AS GSK-3 INHIBITORS | PFIZER PROD INC (US) | 2007-08-08 | — | — | EP | disclosed |