Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.33 |
| ▸ | GSK3A | P49840 | 2/20 | 0.33 |
| ▸ | GSK3B | P49841 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | LPAR2 | Q9HBW0 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5549410 | 0.82 | TLR9 (0.43) | MAPK1GSK3AGSK3BMEN1KMT2A | |
| SCHEMBL3522851 | 0.81 | CXCR2 (0.35) | — | |
| SCHEMBL3526664 | 0.80 | GAA (0.45) | MAPK1GSK3AGSK3BMEN1KMT2A | |
| SCHEMBL5548540 | 0.79 | PDE5A (0.32) | GSK3AGSK3B | |
| SCHEMBL5549388 | 0.78 | IRAK4 (0.33) | — | |
| SCHEMBL5543751 | 0.78 | LMNA (0.39) | MEN1KMT2ASMN1; SMN2GAAALDH1A1 | |
| SCHEMBL5549385 | 0.73 | MAPT (0.42) | — | |
| SCHEMBL5548896 | 0.73 | GRK6 (0.34) | — | |
| SCHEMBL5550127 | 0.72 | CYP3A4 (0.37) | MEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL5548899 | 0.72 | GSK3B (0.32) | GSK3AGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678180-B1 | SUBSTITUTED 2H-[1,2,4]TRIAZOLO 4,3-A PYRAZINES AS GSK-3 INHIBITORS | PFIZER PROD INC (US) | 2007-08-08 | — | — | EP | disclosed |