Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ILK | Q13418 | 2/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA4 | P22748 | 1/20 | 0.34 |
| ▸ | CA7 | P43166 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.34 |
| ▸ | GLP1R | P43220 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | IKBKB | O14920 | 1/20 | 0.33 |
| ▸ | CHUK | O15111 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 7/20 | 0.33 |
| ▸ | GSK3A | P49840 | 6/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3529957 | 0.87 | BRD4 (0.45) | ALDH1A1 | |
| SCHEMBL5545590 | 0.83 | GSK3B (0.35) | ADORA1GSK3BGSK3A | |
| SCHEMBL5545504 | 0.83 | GAA (0.43) | ILKADORA1GSK3BGSK3A | |
| SCHEMBL5543665 | 0.82 | GAA (0.40) | MEN1KMT2AGSK3BGSK3AALDH1A1 | |
| SCHEMBL3522887 | 0.81 | SYK (0.34) | ADORA1GSK3BGSK3A | |
| SCHEMBL5543598 | 0.81 | HSD17B10 (0.43) | ADORA1GSK3BGSK3ACYP2D6HSD17B10 | |
| SCHEMBL3525674 | 0.81 | GSK3B (0.42) | ADORA1GSK3BGSK3AKDM4ETSHR | |
| SCHEMBL5550117 | 0.81 | GAA (0.39) | MEN1KMT2AGSK3BGSK3AALDH1A1 | |
| SCHEMBL5545643 | 0.81 | GSK3B (0.34) | ADORA1GSK3BGSK3A | |
| SCHEMBL5545560 | 0.80 | GSK3A (0.37) | GSK3BGSK3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678180-B1 | SUBSTITUTED 2H-[1,2,4]TRIAZOLO 4,3-A PYRAZINES AS GSK-3 INHIBITORS | PFIZER PROD INC (US) | 2007-08-08 | — | — | EP | disclosed |