Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | GSK3A | P49840 | 14/20 | 0.36 |
| ▸ | GSK3B | P49841 | 14/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CDC25A | P30304 | 1/20 | 0.34 |
| ▸ | CDC25B | P30305 | 1/20 | 0.34 |
| ▸ | SYK | P43405 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5550117 | 0.99 | GAA (0.39) | GAAALDH1A1MEN1GFERKMT2A | |
| SCHEMBL5545504 | 0.97 | GAA (0.43) | GAAGSK3AGSK3BCDC25ACDC25B | |
| SCHEMBL5550132 | 0.82 | ILK (0.35) | ALDH1A1MEN1KMT2AHSD17B10GSK3A | |
| SCHEMBL3521844 | 0.82 | MAT2A (0.38) | ALDH1A1GFERHSD17B10GSK3AGSK3B | |
| SCHEMBL5545643 | 0.79 | GSK3B (0.34) | GSK3AGSK3B | |
| SCHEMBL5548899 | 0.77 | GSK3B (0.32) | GSK3AGSK3B | |
| SCHEMBL5543493 | 0.75 | GSK3B (0.50) | SMN1; SMN2GSK3AGSK3B | |
| SCHEMBL5550070 | 0.73 | GSK3A (0.50) | ALDH1A1MEN1KMT2ASMN1; SMN2L3MBTL1 | |
| SCHEMBL3529299 | 0.72 | GSK3B (0.41) | GSK3AGSK3B | |
| SCHEMBL5550039 | 0.72 | GSK3A (0.46) | MEN1KMT2AGSK3AGSK3BLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678180-B1 | SUBSTITUTED 2H-[1,2,4]TRIAZOLO 4,3-A PYRAZINES AS GSK-3 INHIBITORS | PFIZER PROD INC (US) | 2007-08-08 | — | — | EP | disclosed |