Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | GSK3A | P49840 | 15/20 | 0.36 |
| ▸ | GSK3B | P49841 | 15/20 | 0.36 |
| ▸ | SYK | P43405 | 1/20 | 0.36 |
| ▸ | ILK | Q13418 | 1/20 | 0.35 |
| ▸ | CDC25A | P30304 | 1/20 | 0.34 |
| ▸ | CDC25B | P30305 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5550117 | 0.96 | GAA (0.39) | GAAGSK3AGSK3BSYKCDC25A | |
| SCHEMBL3521844 | 0.83 | MAT2A (0.38) | GSK3AGSK3B | |
| SCHEMBL5550132 | 0.83 | ILK (0.35) | GSK3AGSK3BILKADORA1 | |
| SCHEMBL5545643 | 0.80 | GSK3B (0.34) | GSK3AGSK3BADORA1 | |
| SCHEMBL5548899 | 0.78 | GSK3B (0.32) | GSK3AGSK3BADORA1 | |
| SCHEMBL5543493 | 0.76 | GSK3B (0.50) | GSK3AGSK3BADORA1 | |
| SCHEMBL5550070 | 0.74 | GSK3A (0.50) | GSK3AGSK3B | |
| SCHEMBL3529299 | 0.73 | GSK3B (0.41) | GSK3AGSK3BADORA1 | |
| SCHEMBL5550039 | 0.72 | GSK3A (0.46) | GSK3AGSK3BADORA1 | |
| SCHEMBL3523483 | 0.72 | NPC1 (0.41) | ILKADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678180-B1 | SUBSTITUTED 2H-[1,2,4]TRIAZOLO 4,3-A PYRAZINES AS GSK-3 INHIBITORS | PFIZER PROD INC (US) | 2007-08-08 | — | — | EP | disclosed |