Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 2/20 | 0.59 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.59 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.49 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.43 |
| ▸ | BACE1 | P56817 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | NT5E | P21589 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | LOX | P28300 | 1/20 | 0.39 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.39 |
| ▸ | IGF1R | P08069 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 3/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19150082 | 0.80 | ADORA2A (0.68) | ADORA2AADORA1TLR7ADRB2BACE1 | |
| SCHEMBL8229246 | 0.78 | ADORA2A (0.66) | ADORA2AADORA1TLR7ADRB2BACE1 | |
| SCHEMBL19148213 | 0.77 | ADORA2A (0.64) | ADORA2AADORA1TLR7ADRB2BACE1 | |
| SCHEMBL19149239 | 0.77 | ADORA2A (0.64) | ADORA2AADORA1TLR7ADRB2BACE1 | |
| SCHEMBL8441818 | 0.76 | ADORA2A (0.71) | ADORA2AADORA1TLR7ADRB2BACE1 | |
| SCHEMBL7226777 | 0.75 | ADORA2A (1.00) | ADORA2AADORA1TLR7ADRB2BACE1 | |
| SCHEMBL30106724 | 0.73 | ADORA2A (0.54) | ADORA2AADORA1TLR7ADRB2BACE1 | |
| SCHEMBL30106738 | 0.73 | NCF1 (0.55) | ADORA2AADORA1TLR7ADRB2BACE1 | |
| SCHEMBL2657337 | 0.73 | ADORA2A (0.54) | ADORA2AADORA1TLR7ADRB2BACE1 | |
| SCHEMBL1119951 | 0.73 | NCF1 (0.55) | ADORA2AADORA1TLR7ADRB2BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678180-B1 | SUBSTITUTED 2H-[1,2,4]TRIAZOLO 4,3-A PYRAZINES AS GSK-3 INHIBITORS | PFIZER PROD INC (US) | 2007-08-08 | — | — | EP | disclosed |