Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.41 |
| ▸ | CTSS | P25774 | 1/20 | 0.40 |
| ▸ | CTSK | P43235 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 2/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.36 |
| ▸ | ICMT | O60725 | 1/20 | 0.36 |
| ▸ | GALR1 | P47211 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | MMP3 | P08254 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5551665 | 0.79 | PTGS2 (0.48) | TLR8CTSSCTSKMAOB | |
| SCHEMBL5549699 | 0.77 | CHRNB4 (0.43) | — | |
| SCHEMBL1021059 | 0.76 | TLR8 (0.40) | TLR8CTSSCTSKMAOBHTR2C | |
| SCHEMBL5549746 | 0.74 | RARB (0.40) | HTR2CMMP2MMP3 | |
| SCHEMBL1021436 | 0.74 | TLR8 (0.38) | TLR8CTSSCTSKMAOBHTR2C | |
| SCHEMBL1021437 | 0.74 | TLR8 (0.38) | TLR8CTSSCTSKMAOBHTR2C | |
| SCHEMBL5550509 | 0.72 | MAPK14 (0.46) | — | |
| SCHEMBL28769701 | 0.70 | TLR8 (0.35) | TLR8CTSSCTSKMAOBHDAC3 | |
| SCHEMBL256694 | 0.70 | TAAR1 (0.62) | HRH1HTR2CHDAC1 | |
| SCHEMBL2532289 | 0.69 | HTR2C (0.50) | CTSSMAOBHRH1HRH4HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1841729-A1 | 2-CYCLOPENTEN-1-ONE OXIME DERIVATIVES INHIBITING PRODUCTION OF TNF-ALPHA | Amorepacific Corporation (KR) | 2007-10-10 | — | — | EP | disclosed |
| WO-2006059867-A1 | 2-CYCLOPENTEN-1-ONE OXIME DERIVATIVES INHIBITING PRODUCTION OF TNF-ALPHA | AMOREPACIFIC CORPORATION (KR) | 2006-06-08 | — | — | WO | disclosed |