Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 3/20 | 0.48 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | KIF11 | P52732 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CTSS | P25774 | 1/20 | 0.34 |
| ▸ | CTSK | P43235 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5550486 | 0.79 | TLR8 (0.41) | TLR8MAOBCTSSCTSK | |
| SCHEMBL5550509 | 0.78 | MAPK14 (0.46) | PTGS2PTGS1ADORA3ADORA2AADORA2B | |
| SCHEMBL1022353 | 0.74 | TLR8 (0.37) | PTGS2TLR8MAOBKIF11MEN1 | |
| SCHEMBL9281653 | 0.74 | PTGS2 (0.46) | PTGS2PTGS1TLR8SLC6A4 | |
| SCHEMBL10382748 | 0.73 | MAOB (0.58) | PTGS2PTGS1ADORA3SLC6A2SLC6A4 | |
| SCHEMBL17108417 | 0.73 | MAOB (0.58) | PTGS2PTGS1ADORA3SLC6A2SLC6A4 | |
| SCHEMBL1019953 | 0.71 | TLR8 (0.35) | TLR8ADORA3MAOBKIF11MEN1 | |
| SCHEMBL1019954 | 0.71 | TLR8 (0.35) | TLR8ADORA3MAOBKIF11MEN1 | |
| SCHEMBL8990601 | 0.71 | MAOB (0.56) | PTGS2PTGS1ADORA3SLC6A2SLC6A4 | |
| SCHEMBL10381425 | 0.71 | MAOB (0.56) | PTGS2PTGS1ADORA3SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1841729-A1 | 2-CYCLOPENTEN-1-ONE OXIME DERIVATIVES INHIBITING PRODUCTION OF TNF-ALPHA | Amorepacific Corporation (KR) | 2007-10-10 | — | — | EP | disclosed |
| WO-2006059867-A1 | 2-CYCLOPENTEN-1-ONE OXIME DERIVATIVES INHIBITING PRODUCTION OF TNF-ALPHA | AMOREPACIFIC CORPORATION (KR) | 2006-06-08 | — | — | WO | disclosed |