Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 3/20 | 0.55 |
| ▸ | PPARG | P37231 | 3/20 | 0.55 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.47 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.47 |
| ▸ | IDO1 | P14902 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 3/20 | 0.43 |
| ▸ | CNR1 | P21554 | 2/20 | 0.43 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5115018 | 1.00 | P2RX7 (0.55) | P2RX7PPARGTAS1R3TAS1R1IDO1 | |
| SCHEMBL5643173 | 0.81 | TAS1R3 (0.64) | P2RX7TAS1R3TAS1R1IDO1ALDH1A1 | |
| SCHEMBL5111387 | 0.78 | P2RX7 (0.66) | P2RX7PPARGMEN1KMT2AALDH1A1 | |
| SCHEMBL5119224 | 0.78 | P2RX7 (0.66) | P2RX7PPARGMEN1KMT2AALDH1A1 | |
| SCHEMBL5115009 | 0.77 | P2RX7 (0.63) | P2RX7PPARGMEN1KMT2AALDH1A1 | |
| SCHEMBL5120267 | 0.76 | P2RX7 (0.65) | P2RX7PPARGMEN1KMT2AALDH1A1 | |
| SCHEMBL5120264 | 0.76 | P2RX7 (0.65) | P2RX7PPARGMEN1KMT2AALDH1A1 | |
| SCHEMBL5120270 | 0.76 | P2RX7 (0.65) | P2RX7PPARGMEN1KMT2AALDH1A1 | |
| SCHEMBL4881566 | 0.74 | ALDH1A1 (0.58) | P2RX7MEN1KMT2AALDH1A1GAA | |
| SCHEMBL5119528 | 0.73 | NPC1 (0.67) | P2RX7PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844003-A1 | NOVEL BIAROMATIC COMPOUNDS, INHIBITORS OF THE P2X7-RECEPTOR | AstraZeneca AB (SE) | 2007-10-17 | — | — | EP | disclosed |
| WO-2006080884-A1 | NOVEL BIAROMATIC COMPOUNDS, INHIBITORS OF THE P2X7-RECEPTOR | ASTRAZENECA AB (SE) | 2006-08-03 | — | — | WO | disclosed |