Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | KDM1A | O60341 | 1/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.45 |
| ▸ | ACP1 | P24666 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 3/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | ATR | Q13535 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.40 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.40 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.40 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19806092 | 0.81 | ADORA2A (0.48) | KDM4EALDH1A1KDM1AADORA2AACP1 | |
| SCHEMBL8819450 | 0.76 | KDM1A (0.45) | KDM1AADORA2AACP1MEN1USP2 | |
| SCHEMBL5553119 | 0.76 | EGFR (0.46) | KDM4EALDH1A1KDM1AADORA2AACP1 | |
| SCHEMBL17286874 | 0.75 | KDM4E (0.77) | KDM4EALDH1A1ADORA2ALMNAMAPT | |
| SCHEMBL808191 | 0.75 | KDM4E (0.77) | KDM4EALDH1A1ADORA2ALMNAMAPT | |
| SCHEMBL25723721 | 0.75 | ALDH1A1 (0.62) | KDM4EALDH1A1ADORA2ALMNAMAPT | |
| SCHEMBL808420 | 0.75 | KDM4E (0.77) | KDM4EALDH1A1ADORA2ALMNAMAPT | |
| SCHEMBL3115091 | 0.75 | MEN1 (0.64) | KDM4EKDM1AACP1MAPTMEN1 | |
| SCHEMBL8818302 | 0.74 | KDM1A (0.44) | KDM4EALDH1A1KDM1AADORA2AACP1 | |
| SCHEMBL2879799 | 0.74 | L3MBTL1 (0.41) | ALDH1A1KDM1ALMNAMAPTPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11725000-B2 | Apoptosis inhibitors | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2023-08-15 | — | — | US | disclosed |
| US-11034680-B2 | Apoptosis inhibitors | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2021-06-15 | — | — | US | disclosed |
| EP-3484854-B1 | APOPTOSIS INHIBITORS | NAT INSTITUTE OF BIOLOGICAL SCIENCES BEIJING (CN) | 2021-01-20 | — | — | EP | disclosed |
| US-20190152960-A1 | Apoptosis Inhibitors | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2019-05-23 | — | — | US | disclosed |
| WO-2018014802-A1 | APOPTOSIS INHIBITORS | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2018-01-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190152960-A1 | Apoptosis Inhibitors | BAX, SDHA, SDHB | KDM4E 1117/4885ALDH1A1 550/4885KDM1A 1294/4885 |
| US-11725000-B2 | Apoptosis inhibitors | BAX, SDHA, SDHB | KDM4E 1117/4885ALDH1A1 550/4885KDM1A 1294/4885 |
| US-11034680-B2 | Apoptosis inhibitors | BAX, SDHA, SDHB | KDM4E 1117/4885ALDH1A1 550/4885KDM1A 1294/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.