SCHEMBL5553500

SCHEMBL5553500

O=CN1CCNCC1c1ccccc1

nearest known ligand 0.47

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
HTR2C P28335 4/20 0.42
HTR2B P41595 4/20 0.42
HTR2A P28223 3/20 0.42
SLC6A2 P23975 2/20 0.41
SLC6A4 P31645 2/20 0.41
SLC6A3 Q01959 2/20 0.41
CYP2D6 P10635 1/20 0.41
TAAR1 Q96RJ0 1/20 0.40
HPGD P15428 1/20 0.37
KMT2A Q03164 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
SLC18A3 Q16572 2/20 0.36
SIGMAR1 Q99720 2/20 0.35
HTR3E A5X5Y0 1/20 0.35
HTR3B O95264 1/20 0.35
ADRB1 P08588 1/20 0.35
HTR3A P46098 1/20 0.35
HTR3D Q70Z44 1/20 0.35
HTR3C Q8WXA8 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14831356 1.00 HTR2C (0.42) HTR2CHTR2BHTR2ASLC6A2SLC6A4
Hydrochloric Acid SCHEMBL15173335 0.98 HTR2C (0.41) HTR2CHTR2BHTR2ASLC6A2SLC6A4
SCHEMBL2337017 0.85 DPP4 (0.40) HTR2CHTR2BHTR2A
SCHEMBL31581033 0.84 HTR3A (0.44) HTR2CHTR2BHTR2ACYP2D6SIGMAR1
SCHEMBL2430207 0.83 SLC6A2 (0.41) HTR2CHTR2BHTR2ASLC6A2SLC6A4
SCHEMBL2336871 0.83 RIPK1 (0.40) HTR2CHTR2BHTR2A
SCHEMBL29200484 0.82 SLC6A4 (0.42) HTR2CHTR2BHTR2ASLC6A2SLC6A4
SCHEMBL27603668 0.82 ALDH1A1 (0.45) KMT2AHTR3EHTR3BHTR3AHTR3D
SCHEMBL10772882 0.81 SLC6A2 (0.40) HTR2CHTR2BHTR2ASLC6A2SLC6A4
SCHEMBL28961386 0.81 SLC6A2 (0.40) HTR2CHTR2BHTR2ASLC6A2SLC6A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109134433-B Compound for inhibiting ROCK and application thereof 成都先导药物开发股份有限公司 2021-05-25 CN disclosed
EP-2760862-A1 6-(4-HYDROXY-PHENYL)-3-ALKYL-1H-PYRAZOLO[3,4-B]PYRIDINE-4-CARBOXYLIC ACID AMIDE DERIVATIVES AS KINASE INHIBITORS SANOFI (FR) 2014-08-06 EP disclosed
WO-2013045413-A1 6-(4-HYDROXY-PHENYL)-3-ALKYL-1H-PYRAZOLO[3,4-B]PYRIDINE-4-CARBOXYLIC ACID AMIDE DERIVATIVES AS KINASE INHIBITORS SANOFI (FR) 2013-04-04 WO disclosed
WO-2011067306-A1 CYCLOHEXANE DERIVATIVES AS INHIBITORS OF ACETYL-COA CARBOXYLASE (ACC) NOVARTIS AG (CH) 2011-06-09 WO disclosed
EP-1581538-B1 TETRACYCLIC 3-SUBSTITUTED INDOLES HAVING SEROTONIN RECEPTOR AFFINITY SUVEN LIFE SCIENCES LTD (IN) 2007-02-28 EP disclosed
EP-0833820-B1 BENZISOXAZOLE AND INDAZOLE DERIVATIVES AS ANTIPSYCHOTIC AGENTS AVENTIS PHARMA INC (US) 2001-02-14 EP disclosed
US-6008348-A TREATING A 1-TOSYLATED INDAZOL-3-YL PIPERAZINE DERIVATIVE WITH CONCENTRATED HYDROCHLORIC ACID TO PRODUCE THE DETOSYLATED INDAZOL-3-YL PIPERAZINE COMPOUND OF GIVEN FORMULA HOECHST MARION ROUSSEL, INC. (US) 1999-12-28 US disclosed
US-5965554-A PIPERAZINYLBENZISOXAZOLE DERIVATIVES HOECHST MARION ROUSSEL, INC. (US) 1999-10-12 US disclosed
US-5852022-A Antipsychotic agents, composition and method of use HOECHST ROUSSEL PHARMACEUTICALS INC. (US) 1998-12-22 US disclosed
CN-1187192-A Benzisoxazole and indazole derivatives as antipsychotic agents HOECHST MARION ROUSSEL INC (US) 1998-07-08 CN disclosed
EP-0833820-A1 BENZISOXAZOLE AND INDAZOLE DERIVATIVES AS ANTIPSYCHOTIC AGENTS HOECHST MARION ROUSSEL, INC. (US) 1998-04-08 EP disclosed
US-5696113-A Antipsychotic agents, compositions and method of use HOECHST MARION ROUSSEL, INC. (US) 1997-12-09 US disclosed
WO-1996039397-A1 BENZISOXAZOLE AND INDAZOLE DERIVATIVES AS ANTIPSYCHOTIC AGENTS HOECHST MARION ROUSSEL, INC. (US) 1996-12-12 WO disclosed
CN-1022632-C Carboxamide compounds, process for preparing same and pharmaceutical composition containing same OTSUKA PHARMA CO LTD (JP) 1993-11-03 CN disclosed
US-4971957-A ANTILIPEMIC AGENTS, ANTICHOLESTEROL AGENTS, BENZENECARBOXAMIDOPHOSPHONATES OR BENZENETHIOCARBOXAMIDOPHOSPHONATES OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) 1990-11-20 US disclosed
CN-1040029-A Carboxylic acid amide compounds and preparation method thereof and contain the pharmaceutical composition of this carboxylic acid amine compound OTSUKA PHARMA CO LTD (JP) 1990-02-28 CN disclosed