Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 4/20 | 0.39 |
| ▸ | AKR1C2 | P52895 | 4/20 | 0.39 |
| ▸ | BCL2 | P10415 | 1/20 | 0.38 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 4/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | PRKACA | P17612 | 3/20 | 0.34 |
| ▸ | PRKACG | P22612 | 3/20 | 0.34 |
| ▸ | PRKACB | P22694 | 3/20 | 0.34 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.34 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5800049 | 0.90 | KMT2A (0.37) | MAPTHTTAKR1C3AKR1C2SRC | |
| SCHEMBL5558604 | 0.89 | SRC (0.47) | AKR1C3AKR1C2BCL2MDM2MCL1 | |
| SCHEMBL5558979 | 0.87 | AKR1C3 (0.39) | AKR1C3AKR1C2 | |
| SCHEMBL5559667 | 0.87 | PTGS2 (0.35) | MAPTHTTAKR1C3AKR1C2SRC | |
| SCHEMBL5560264 | 0.87 | PTGS2 (0.35) | MAPTHTTAKR1C3AKR1C2SRC | |
| SCHEMBL5559414 | 0.86 | LMNA (0.40) | MAPTHTTLMNAAKR1C3AKR1C2 | |
| SCHEMBL5560588 | 0.84 | MAPT (0.39) | MAPTHTTLMNAAKR1C3AKR1C2 | |
| SCHEMBL6423406 | 0.80 | KMT2A (0.37) | MAPTHTTKDM4ETP53GAA | |
| SCHEMBL3005516 | 0.80 | — | — | |
| SCHEMBL5553765 | 0.80 | AKR1C3 (0.45) | MAPTHTTLMNAAKR1C3AKR1C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1643961-A4 | COX-2 AND FAAH INHIBITORS | MICROBIA INC (US) | 2007-09-12 | — | — | EP | disclosed |
| EP-1643961-A2 | COX-2 AND FAAH INHIBITORS | Microbia, Inc. (US) | 2006-04-12 | — | — | EP | disclosed |
| WO-2005002525-A2 | COX-2 AND FAAH INHIBITORS | MICROBIA, INC. (US) | 2005-01-13 | — | — | WO | disclosed |