⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7127146 | 0.82 | GAA (0.40) | — | |
| SCHEMBL5553336 | 0.82 | GAA (0.40) | — | |
| SCHEMBL13059598 | 0.79 | KARS1 (0.32) | — | |
| SCHEMBL1734564 | 0.79 | KARS1 (0.32) | — | |
| SCHEMBL5554373 | 0.75 | CYP2D6 (0.36) | — | |
| SCHEMBL3764731 | 0.75 | CYP2C19 (0.38) | — | |
| SCHEMBL19809987 | 0.75 | CYP2C19 (0.38) | — | |
| SCHEMBL5555360 | 0.75 | CYP2C19 (0.38) | — | |
| SCHEMBL5549643 | 0.71 | — | — | |
| SCHEMBL12153167 | 0.71 | ATP1A1 (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7285546-B2 | Cephalotaxanes, their method of preparation and their use in treatment of cancers, leukemias, parasites including those resistant to usual chemotherapeutic agents and as reversal agents | STRAGEN PHARMA S.A. (CH) | 2007-10-23 | — | — | US | disclosed |
| EP-1328527-B1 | CEPHALOTAXANES, THEIR METHOD OF PREPARATION AND THEIR USE IN TREATMENT OF CANCERS, LEUKEMIAS, PARASITES INCLUDING THOSE RESISTANT TO USUAL CHEMOTHERAPEUTIC AGENTS AND AS REVERSAL AGENTS | STRAGEN PHARMA SA (CH) | 2006-03-08 | — | — | EP | disclosed |
| US-20040006064-A1 | Cephalotaxanes, their method of preparation and their use in treatment of cancers, leukemias, parasites including those resistant to usual chemotherapeutic agents and as reversal agents | IVAX International GmbH (CH) | 2004-01-08 | — | — | US | disclosed |
| EP-1328527-A1 | CEPHALOTAXANES, THEIR METHOD OF PREPARATION AND THEIR USE IN TREATMENT OF CANCERS, LEUKEMIAS, PARASITES INCLUDING THOSE RESISTANT TO USUAL CHEMOTHERAPEUTIC AGENTS AND AS REVERSAL AGENTS | Oncopharm Corporation (US) | 2003-07-23 | — | — | EP | disclosed |
| WO-2002032904-A1 | NEW CEPHALOTAXANES, THEIR METHOD OF PREPARATION AND THEIR USE IN TREATMENT OF CANCERS, LEUKEMIAS, PARASITES INCLUDING THUS RESISTANT TO USUAL CHEMOTHERAPEUTIC AGENTS AND AS REVERSAL AGENTS | ONCOPHARM CORPORATION (FR) | 2002-04-25 | — | — | WO | disclosed |