Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 2/20 | 0.32 |
| ▸ | ATP1A1 | P05023 | 1/20 | 0.31 |
| ▸ | ATP1B1 | P05026 | 1/20 | 0.31 |
| ▸ | ATP1A3 | P13637 | 1/20 | 0.31 |
| ▸ | ATP1B2 | P14415 | 1/20 | 0.31 |
| ▸ | ATP1A2 | P50993 | 1/20 | 0.31 |
| ▸ | ATP1B3 | P54709 | 1/20 | 0.31 |
| ▸ | FXYD2 | P54710 | 1/20 | 0.31 |
| ▸ | ATP1A4 | Q13733 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13059598 | 1.00 | KARS1 (0.32) | KARS1ATP1A1ATP1B1ATP1A3ATP1B2 | |
| SCHEMBL1462631 | 0.90 | TP53 (0.33) | KARS1TP53 | |
| SCHEMBL1462630 | 0.90 | TP53 (0.33) | KARS1TP53 | |
| Cyclohexylamine SCHEMBL27710809 | 0.88 | KARS1 (0.31) | KARS1ATP1A1ATP1B1ATP1A3ATP1B2 | |
| SCHEMBL19809999 | 0.87 | NPSR1 (0.33) | ATP1A1ATP1B1ATP1A3ATP1B2ATP1A2 | |
| SCHEMBL12393353 | 0.87 | NPSR1 (0.33) | ATP1A1ATP1B1ATP1A3ATP1B2ATP1A2 | |
| SCHEMBL7127146 | 0.84 | GAA (0.40) | — | |
| SCHEMBL5553336 | 0.84 | GAA (0.40) | — | |
| SCHEMBL12153167 | 0.84 | ATP1A1 (0.39) | ATP1A1ATP1B1ATP1A3ATP1B2ATP1A2 | |
| SCHEMBL5554373 | 0.83 | CYP2D6 (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 45 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018019549-A1 | DIOXOLANONE INTERMEDIATE USEFUL IN THE SYNTHESIS OF HOMOHARRINGTONINE | INDENA S.P.A. (IT) | 2018-02-01 | — | — | WO | claimed |
| EP-3275875-A1 | DIOXOLANONE INTERMEDIATE USEFUL IN THE SYNTHESIS OF HOMOHARRINGTONINE | INDENA S.p.A. (IT) | 2018-01-31 | — | — | EP | claimed |
| EP-1907371-B1 | PROCESS FOR PREPARING 2-METHOXYCARBONYLMETHYL-6,6-DIMETHYL-2- TETRAHYDROPYRAN CARBOXYLIC ACID | ERREGIERRE SPA (IT) | 2011-11-23 | — | — | EP | claimed |
| US-8008514-B2 | Process for preparing 2-methoxycarbonylmethyl-6,6-dimethyl-2-tetrahydropyran carboxylic acid | ERREGIERRE S.P.A. (IT) | 2011-08-30 | — | — | US | claimed |
| CN-101233123-B | Process for the preparation of 2-methoxycarbonylmethyl-6, 6-dimethyl-2-tetrahydropyran carboxylic acid | ERREGIERRE SPA | 2011-05-11 | — | — | CN | claimed |
| US-20090043093-A1 | Process for Preparing 2-Methoxycarbonylmethyl-6,6-Dimethyl-2-Tetrahydropyran Carboxylic Acid | STRAGEN PHARMA SA (CH) | 2009-02-12 | — | — | US | claimed |
| EP-1907371-A1 | PROCESS FOR PREPARING 2-METHOXYCARBONYLMETHYL-6,6-DIMETHYL-2- TETRAHYDROPYRAN CARBOXYLIC ACID | ERREGIERRE S.p.A. (IT) | 2008-04-09 | — | — | EP | claimed |
| WO-2007009953-A1 | PROCESS FOR PREPARING 2-METHOXYCARBONYLMETHYL-6,6-DIMETHYL-2- TETRAHYDROPYRAN CARBOXYLIC ACID | ERREGIERRE S.P.A. (IT) | 2007-01-25 | — | — | WO | claimed |
| WO-2018019549-A1 | DIOXOLANONE INTERMEDIATE USEFUL IN THE SYNTHESIS OF HOMOHARRINGTONINE | INDENA S.P.A. (IT) | 2018-02-01 | — | — | WO | disclosed |
| WO-2018019549-A1 | DIOXOLANONE INTERMEDIATE USEFUL IN THE SYNTHESIS OF HOMOHARRINGTONINE | INDENA S.P.A. (IT) | 2018-02-01 | — | — | WO | disclosed |
| WO-2018019549-A1 | DIOXOLANONE INTERMEDIATE USEFUL IN THE SYNTHESIS OF HOMOHARRINGTONINE | INDENA S.P.A. (IT) | 2018-02-01 | — | — | WO | disclosed |
| EP-3275875-A1 | DIOXOLANONE INTERMEDIATE USEFUL IN THE SYNTHESIS OF HOMOHARRINGTONINE | INDENA S.p.A. (IT) | 2018-01-31 | — | — | EP | disclosed |
| EP-3275875-A1 | DIOXOLANONE INTERMEDIATE USEFUL IN THE SYNTHESIS OF HOMOHARRINGTONINE | INDENA S.p.A. (IT) | 2018-01-31 | — | — | EP | disclosed |
| EP-3275875-A1 | DIOXOLANONE INTERMEDIATE USEFUL IN THE SYNTHESIS OF HOMOHARRINGTONINE | INDENA S.p.A. (IT) | 2018-01-31 | — | — | EP | disclosed |
| EP-1064285-B1 | NOVEL CEPHALOTAXANE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | STRAGEN PHARMA SA (CH) | 2005-02-16 | — | — | EP | disclosed |
| US-6831180-B1 | Substituted tertiary carboxylic oxacycloalkane acids, used to prepare anhydro-homo-harringtonic acids by semi-synthesis; hydroxyl function of a cephalotaxane is esterified with a 2-carboxyl-2-alkyl-1-oxacycloalkane claimed intermediate; (indexing from 7169774 added) | STRAGEN PHARMA SA. (CH) | 2004-12-14 | — | — | US | disclosed |
| US-6613900-B2 | Asymetric hemisynthesis of harringtonines and their analogs, that are alkaloids used in chemotherapy. | ONCOPHARM CORPORATION | 2003-09-02 | — | — | US | disclosed |
| US-20020045750-A1 | Asymetric hemisynthesis of harringtonines and their analogs, that are alkaloids used in chemotherapy. | IVAX International GmbH (CH) | 2002-04-18 | — | — | US | disclosed |
| EP-1064285-A1 | NOVEL CEPHALOTAXANE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | Oncopharm Corporation (US) | 2001-01-03 | — | — | EP | disclosed |
| WO-1999048894-A1 | NOVEL CEPHALOTAXANE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | ONCOPHARM CORPORATION (US) | 1999-09-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020045750-A1 | Asymetric hemisynthesis of harringtonines and their analogs, that are alkaloids used in chemotherapy. | AAAS, AARS1, AADAT | KARS1 93/4885ATP1A1 4114/4885ATP1B1 3744/4885 |
| US-20090043093-A1 | Process for Preparing 2-Methoxycarbonylmethyl-6,6-Dimethyl-2-Tetrahydropyran Carboxylic Acid | HPD, ACMSD, MVD | KARS1 3369/4885ATP1A1 4226/4885ATP1B1 4511/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.