Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 7/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.31 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5560065 | 0.93 | PTGS2 (0.31) | PTGS2AKR1C3AKR1C2 | |
| SCHEMBL5813879 | 0.89 | AKR1C3 (0.38) | PTGS2MEN1KMT2AAKR1C3AKR1C2 | |
| SCHEMBL5554427 | 0.86 | MEN1 (0.32) | PTGS2MEN1KMT2A | |
| SCHEMBL5560536 | 0.85 | KMT2A (0.36) | PTGS2MEN1KMT2AAKR1C3AKR1C2 | |
| SCHEMBL5554454 | 0.83 | PTGS2 (0.40) | PTGS2MEN1KMT2AAKR1C3AKR1C2 | |
| SCHEMBL5558659 | 0.80 | PTGS2 (0.39) | PTGS2AKR1C3AKR1C2 | |
| SCHEMBL5560071 | 0.80 | PTGS2 (0.39) | PTGS2AKR1C3AKR1C2 | |
| SCHEMBL5554202 | 0.77 | TACR3 (0.33) | PTGS2AKR1C3AKR1C2 | |
| SCHEMBL5558629 | 0.77 | AKR1C3 (0.37) | PTGS2AKR1C3AKR1C2 | |
| SCHEMBL5559390 | 0.77 | AKR1C3 (0.42) | PTGS2MEN1KMT2AAKR1C3AKR1C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1643961-A4 | COX-2 AND FAAH INHIBITORS | MICROBIA INC (US) | 2007-09-12 | — | — | EP | disclosed |
| EP-1643961-A2 | COX-2 AND FAAH INHIBITORS | Microbia, Inc. (US) | 2006-04-12 | — | — | EP | disclosed |
| WO-2005002525-A2 | COX-2 AND FAAH INHIBITORS | MICROBIA, INC. (US) | 2005-01-13 | — | — | WO | disclosed |