Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 3/20 | 0.37 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 7/20 | 0.35 |
| ▸ | ELANE | P08246 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | LDHA | P00338 | 1/20 | 0.31 |
| ▸ | LDHB | P07195 | 1/20 | 0.31 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5558659 | 0.93 | PTGS2 (0.39) | AKR1C3AKR1C2PTGS2 | |
| SCHEMBL5560071 | 0.93 | PTGS2 (0.39) | AKR1C3AKR1C2PTGS2 | |
| SCHEMBL5554427 | 0.91 | MEN1 (0.32) | PTGS2LDHALDHBAKR1B1 | |
| SCHEMBL5554230 | 0.91 | AKR1C3 (0.39) | AKR1C3AKR1C2LDHALDHB | |
| SCHEMBL5554255 | 0.91 | AKR1C3 (0.39) | AKR1C3AKR1C2LDHALDHB | |
| SCHEMBL5559997 | 0.90 | PPARG (0.33) | AKR1C3AKR1C2PTGS2 | |
| SCHEMBL5558223 | 0.82 | PTGS2 (0.35) | AKR1C3AKR1C2PTGS2 | |
| SCHEMBL5558485 | 0.80 | PPARG (0.36) | AKR1C3AKR1C2PTGS2POLB | |
| SCHEMBL5558706 | 0.80 | PPARG (0.36) | AKR1C3AKR1C2PTGS2POLB | |
| SCHEMBL5560599 | 0.78 | LMNA (0.39) | AKR1C3AKR1C2ELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1643961-A4 | COX-2 AND FAAH INHIBITORS | MICROBIA INC (US) | 2007-09-12 | — | — | EP | disclosed |
| EP-1643961-A2 | COX-2 AND FAAH INHIBITORS | Microbia, Inc. (US) | 2006-04-12 | — | — | EP | disclosed |
| WO-2005002525-A2 | COX-2 AND FAAH INHIBITORS | MICROBIA, INC. (US) | 2005-01-13 | — | — | WO | disclosed |