Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 6/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | PTGES | O14684 | 1/20 | 0.35 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.35 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.35 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.35 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | ALB | P02768 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5554636 | 0.90 | POLB (0.36) | PPARGPTGS2POLBMEN1LMNA | |
| SCHEMBL5560625 | 0.86 | MAPT (0.37) | PPARGMAPTRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL5554632 | 0.86 | PTGS1 (0.39) | PPARGMAPTRAB9APTGS2PTGS1 | |
| SCHEMBL5554036 | 0.84 | PTGS2 (0.42) | PPARGPTGS2PTGS1AKR1C3AKR1C2 | |
| SCHEMBL5558485 | 0.81 | PPARG (0.36) | PPARGPTGS2PTGS1POLBAKR1C3 | |
| SCHEMBL5558706 | 0.81 | PPARG (0.36) | PPARGPTGS2PTGS1POLBAKR1C3 | |
| SCHEMBL5800575 | 0.80 | PTGS2 (0.43) | PPARGMAPTRAB9APTGS2PTGS1 | |
| SCHEMBL5559588 | 0.79 | PTGS1 (0.36) | PPARGMAPTRAB9APTGS2PTGS1 | |
| SCHEMBL5559997 | 0.77 | PPARG (0.33) | PPARGSMN1; SMN2PTGS2LMNAAKR1C3 | |
| SCHEMBL5558673 | 0.77 | PTGS2 (0.43) | PPARGMAPTRAB9APTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1643961-A4 | COX-2 AND FAAH INHIBITORS | MICROBIA INC (US) | 2007-09-12 | — | — | EP | disclosed |
| EP-1643961-A2 | COX-2 AND FAAH INHIBITORS | Microbia, Inc. (US) | 2006-04-12 | — | — | EP | disclosed |
| WO-2005002525-A2 | COX-2 AND FAAH INHIBITORS | MICROBIA, INC. (US) | 2005-01-13 | — | — | WO | disclosed |