Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 7/20 | 0.52 |
| ▸ | SIRT1 | Q96EB6 | 5/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | SIRT3 | Q9NTG7 | 4/20 | 0.43 |
| ▸ | BCL3 | P20749 | 4/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5555082 | 0.78 | HDAC1 (0.46) | SIRT2SIRT1SIRT3 | |
| SCHEMBL5555071 | 0.78 | HDAC4 (0.49) | — | |
| SCHEMBL3504679 | 0.76 | HDAC1 (0.53) | SIRT2SIRT1LMNA | |
| SCHEMBL8269342 | 0.76 | HDAC1 (0.53) | SIRT2SIRT1LMNA | |
| SCHEMBL5557063 | 0.76 | SIRT2 (0.53) | SIRT2SIRT1SIRT3 | |
| SCHEMBL7284529 | 0.68 | ALDH1A1 (0.60) | ALDH1A1POLB | |
| SCHEMBL8689559 | 0.68 | ALDH1A1 (0.62) | ALDH1A1POLBBCL3GAALMNA | |
| SCHEMBL22861876 | 0.67 | ALDH1A1 (0.53) | ALDH1A1LMNAMAPTPKM | |
| SCHEMBL3503190 | 0.67 | HDAC2 (0.55) | SIRT2SIRT1 | |
| SCHEMBL8269350 | 0.67 | HDAC2 (0.55) | SIRT2SIRT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1784194-A1 | HISTONE DEACETYLASE INHIBITORS | Merck & Co., Inc. (US) | 2007-05-16 | — | — | EP | claimed |
| WO-2006026260-A1 | HISTONE DEACETYLASE INHIBITORS | MERCK & CO., INC. (US) | 2006-03-09 | — | — | WO | claimed |