Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 5/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.49 |
| ▸ | CTSK | P43235 | 5/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.48 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.48 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.48 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.48 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.48 |
| ▸ | CTSS | P25774 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21442769 | 0.81 | HDAC4 (0.52) | HDAC4HDAC1CTSKHDAC3HDAC7 | |
| SCHEMBL5557063 | 0.79 | SIRT2 (0.53) | HDAC4HDAC1HDAC3HDAC7HDAC2 | |
| SCHEMBL5555082 | 0.78 | HDAC1 (0.46) | HDAC4HDAC1CTSKHDAC2HDAC6 | |
| SCHEMBL30091853 | 0.78 | HDAC4 (0.53) | HDAC4HDAC1CTSKHDAC3HDAC7 | |
| SCHEMBL5555087 | 0.78 | SIRT2 (0.52) | — | |
| SCHEMBL23454631 | 0.78 | HDAC4 (0.65) | HDAC4HDAC1CTSKHDAC3HDAC7 | |
| SCHEMBL26436622 | 0.78 | HDAC4 (0.65) | HDAC4HDAC1CTSKHDAC3HDAC7 | |
| SCHEMBL10163667 | 0.78 | RXFP1 (0.52) | HDAC4HDAC1CTSKHDAC3HDAC7 | |
| SCHEMBL8142516 | 0.77 | CTSK (0.61) | HDAC4HDAC1CTSKHDAC6CTSS | |
| SCHEMBL15598266 | 0.77 | CTSK (0.51) | HDAC4HDAC1CTSKHDAC8CTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1784194-A1 | HISTONE DEACETYLASE INHIBITORS | Merck & Co., Inc. (US) | 2007-05-16 | — | — | EP | claimed |
| WO-2006026260-A1 | HISTONE DEACETYLASE INHIBITORS | MERCK & CO., INC. (US) | 2006-03-09 | — | — | WO | claimed |
| EP-1784194-A1 | HISTONE DEACETYLASE INHIBITORS | Merck & Co., Inc. (US) | 2007-05-16 | — | — | EP | disclosed |
| WO-2006026260-A1 | HISTONE DEACETYLASE INHIBITORS | MERCK & CO., INC. (US) | 2006-03-09 | — | — | WO | disclosed |