Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMEM97 | Q5BJF2 | 3/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28888033 | 0.81 | TSHR (0.36) | TMEM97SIGMAR1ALDH1A1HTR2BNPC1 | |
| SCHEMBL6494508 | 0.78 | ALDH1A1 (0.39) | TMEM97SIGMAR1ALDH1A1HTR2BTSHR | |
| SCHEMBL27740112 | 0.74 | TSHR (0.41) | ALDH1A1NPC1RAB9ATSHR | |
| SCHEMBL11477946 | 0.73 | AGXT (0.34) | ALDH1A1NPC1RAB9A | |
| SCHEMBL29552477 | 0.72 | TSHR (0.43) | TMEM97SIGMAR1ALDH1A1HTR2BTSHR | |
| SCHEMBL7294202 | 0.72 | TSHR (0.43) | TMEM97SIGMAR1ALDH1A1HTR2BTSHR | |
| SCHEMBL11738902 | 0.68 | TSHR (0.39) | ALDH1A1TSHR | |
| SCHEMBL11774104 | 0.67 | IDO1 (0.36) | ALDH1A1TSHR | |
| SCHEMBL11634906 | 0.67 | MEN1 (0.51) | NPC1RAB9A | |
| SCHEMBL11633923 | 0.67 | MEN1 (0.51) | NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1398315-B1 | Anti-inflammatory oxo-derivatives and hydroxy derivatives of pyrrolizines, and their pharmaceutical use | MERCKLE GMBH (DE) | 2007-08-08 | — | — | EP | disclosed |
| EP-1398315-A1 | Anti-inflammatory oxo-derivatives and hydroxy derivatives of pyrrolizines, and their pharmaceutical use | MERCKLE GMBH (DE) | 2004-03-17 | — | — | EP | disclosed |
| WO-2001005792-A9 | ANTI-INFLAMMATORY OXO DERIVATIVES AND HYDROXY DERIVATIVES OF PYRROLIZINES, AND THEIR PHARMACEUTICAL USE | MERCKLE GMBH (DE) | 2002-08-29 | — | — | WO | disclosed |