Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | POLQ | O75417 | 1/20 | 0.46 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1114949 | 0.95 | HDAC6 (0.50) | KDM4EALDH1A1LMNAPOLBKMT2A | |
| SCHEMBL7364770 | 0.89 | KMT2A (0.53) | KDM4EALDH1A1LMNAPOLBKMT2A | |
| SCHEMBL7110776 | 0.86 | FOLH1 (0.47) | KDM4EALDH1A1LMNAPOLBKMT2A | |
| SCHEMBL1114979 | 0.86 | FOLH1 (0.47) | KDM4EALDH1A1LMNAPOLBKMT2A | |
| SCHEMBL23054897 | 0.85 | ALDH1A1 (0.51) | KDM4EALDH1A1LMNAPOLBKMT2A | |
| SCHEMBL6360336 | 0.85 | TP53 (0.51) | KDM4EALDH1A1LMNAPOLBKMT2A | |
| SCHEMBL16353651 | 0.84 | KDM4E (0.46) | KDM4EALDH1A1LMNAPOLBKMT2A | |
| SCHEMBL11233840 | 0.84 | FOLH1 (0.46) | KDM4EALDH1A1LMNAPOLBKMT2A | |
| SCHEMBL7110802 | 0.84 | FOLH1 (0.46) | KDM4EALDH1A1LMNAPOLBKMT2A | |
| SCHEMBL1114895 | 0.84 | ALDH1A1 (0.49) | KDM4EALDH1A1LMNAPOLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756039-A4 | COMPOUNDS AND COMPOSITIONS FOR DELIVERING ACTIVE AGENTS | EMISPHERE TECH INC (US) | 2007-05-02 | — | — | EP | disclosed |
| EP-1756039-A2 | COMPOUNDS AND COMPOSITIONS FOR DELIVERING ACTIVE AGENTS | Emisphere Technologies, Inc. (US) | 2007-02-28 | — | — | EP | disclosed |
| WO-2005112633-A2 | COMPOUNDS AND COMPOSITIONS FOR DELIVERING ACTIVE AGENTS | EMISPHERE TECHNOLOGIES, INC. (US) | 2005-12-01 | — | — | WO | disclosed |
| EP-0506468-B1 | N-substituted 4-phenyl-piperidine opioid-antagonists | LILLY CO ELI (US) | 1995-04-26 | — | — | EP | disclosed |
| US-5270328-A | Peripherally selective piperidine opioid antagonists | ELI LILLY AND COMPANY (US) | 1993-12-14 | — | — | US | disclosed |
| US-5159081-A | INTERMEDIATES OF PERIPHERALLY SELECTIVE N-CARBONYL-3,4,4-TRISUBSTITUTED PIPERIDINE OPIOID ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1992-10-27 | — | — | US | disclosed |
| EP-0506468-A1 | N-substituted 4-phenyl-piperidine opioid-antagonists | ELI LILLY AND COMPANY (US) | 1992-09-30 | — | — | EP | disclosed |