Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.63 |
| ▸ | RAB9A | P51151 | 3/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.63 |
| ▸ | POLB | P06746 | 2/20 | 0.63 |
| ▸ | NPC1 | O15118 | 1/20 | 0.63 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | XDH | P47989 | 1/20 | 0.49 |
| ▸ | RARA | P10276 | 1/20 | 0.49 |
| ▸ | RARB | P10826 | 1/20 | 0.49 |
| ▸ | RARG | P13631 | 1/20 | 0.49 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.48 |
| ▸ | CASP3 | P42574 | 1/20 | 0.48 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.48 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.48 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.48 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3417072 | 0.87 | KDM4E (0.61) | KDM4ERAB9ASMN1; SMN2POLBNPC1 | |
| SCHEMBL3995172 | 0.85 | RARA (0.60) | KDM4ESMN1; SMN2NPC1MAPTKMT2A | |
| SCHEMBL6503223 | 0.84 | RARA (0.49) | KDM4ERAB9ASMN1; SMN2POLBNPC1 | |
| SCHEMBL6504818 | 0.84 | RAB9A (0.44) | KDM4ERAB9ASMN1; SMN2POLBNPC1 | |
| SCHEMBL29462096 | 0.83 | KDM4E (0.57) | KDM4ERAB9ASMN1; SMN2POLBNPC1 | |
| SCHEMBL6495754 | 0.83 | MDM2 (0.47) | KDM4ERAB9ASMN1; SMN2POLBNPC1 | |
| SCHEMBL9823302 | 0.81 | PTGDR2 (0.53) | KDM4ERAB9ASMN1; SMN2NPC1MAPT | |
| SCHEMBL5192550 | 0.81 | KDM4E (0.55) | KDM4ERAB9ASMN1; SMN2POLBNPC1 | |
| SCHEMBL6503373 | 0.80 | L3MBTL1 (0.57) | KDM4ERAB9ASMN1; SMN2POLBNPC1 | |
| SCHEMBL14064272 | 0.80 | RAB9A (0.48) | KDM4ERAB9ASMN1; SMN2POLBNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6884821-B1 | Carboxylic acid derivatives and drugs containing the same | EISAI CO., LTD. (JP) | 2005-04-26 | — | — | US | disclosed |
| EP-1216980-A1 | CARBOXYLIC ACID DERIVATIVES AND DRUGS CONTAINING THE SAME | Eisai Co., Ltd. (JP) | 2002-06-26 | — | — | EP | disclosed |