Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.34 |
| ▸ | BCHE | P06276 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.33 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5556226 | 0.90 | LMNA (0.41) | MAPTHCRTR1HCRTR2TSHRKCNA5 | |
| SCHEMBL5555802 | 0.89 | HCRTR1 (0.38) | KMT2AMAPTHCRTR1HCRTR2MEN1 | |
| SCHEMBL5556322 | 0.86 | KMT2A (0.44) | KMT2AMAPTHCRTR1HCRTR2MEN1 | |
| SCHEMBL5556238 | 0.78 | KCNA5 (0.43) | KMT2AMAPTHCRTR1HCRTR2TSHR | |
| SCHEMBL5560808 | 0.77 | KCNA5 (0.37) | KMT2AMAPTHCRTR1HCRTR2MEN1 | |
| SCHEMBL5562883 | 0.76 | ITGB2 (0.31) | KMT2AMAPTMEN1GAAL3MBTL1 | |
| SCHEMBL5555488 | 0.76 | LMNA (0.40) | KMT2AMAPTHCRTR1HCRTR2MEN1 | |
| SCHEMBL5561784 | 0.73 | BCHE (0.45) | KMT2AMAPTMEN1BCHETSHR | |
| SCHEMBL5560845 | 0.71 | MAPT (0.40) | MAPTKCNA5GAA | |
| SCHEMBL5555549 | 0.70 | HCRTR1 (0.40) | KMT2AMAPTHCRTR1HCRTR2KCNA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1631296-B1 | 2,3,4,5-TETRAHYDROBENZO¬F|¬1,4|OXAZEPINE-5-CARBOXYLIC ACID AMIDE DERIVATIVES AS GAMMA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | HOFFMANN LA ROCHE (CH) | 2007-04-25 | — | — | EP | claimed |