Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 1/20 | 0.38 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.36 |
| ▸ | RELA | Q04206 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5556007 | 0.89 | KMT2A (0.39) | HCRTR1HCRTR2MAPTGAAKMT2A | |
| SCHEMBL5555488 | 0.88 | LMNA (0.40) | HCRTR1HCRTR2MAPTSMN1; SMN2LMNA | |
| SCHEMBL5556226 | 0.86 | LMNA (0.41) | HCRTR1HCRTR2MAPTLMNATP53 | |
| SCHEMBL5562156 | 0.80 | ADRB2 (0.36) | MAPTLMNAMAPK1TP53KMT2A | |
| SCHEMBL5561753 | 0.79 | ALDH1A1 (0.39) | MAPTSMN1; SMN2LMNAMAPK1POLB | |
| SCHEMBL5561387 | 0.78 | GAA (0.40) | MAPTSMN1; SMN2LMNAMAPK1NFKB1 | |
| SCHEMBL5561380 | 0.76 | F2 (0.45) | SMN1; SMN2LMNAMAPK1KDM4EKMT2A | |
| SCHEMBL5556322 | 0.76 | KMT2A (0.44) | HCRTR1HCRTR2MAPTTP53GAA | |
| SCHEMBL5556238 | 0.74 | KCNA5 (0.43) | HCRTR1HCRTR2MAPTLMNATP53 | |
| SCHEMBL5562398 | 0.73 | MAPT (0.39) | MAPTSMN1; SMN2LMNAKDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1631296-B1 | 2,3,4,5-TETRAHYDROBENZO¬F|¬1,4|OXAZEPINE-5-CARBOXYLIC ACID AMIDE DERIVATIVES AS GAMMA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | HOFFMANN LA ROCHE (CH) | 2007-04-25 | — | — | EP | claimed |