Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB2 | P05107 | 1/20 | 0.31 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.31 |
| ▸ | ITGAL | P20701 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | MAPT | P10636 | 3/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.30 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5556744 | 0.86 | KCNA5 (0.32) | ITGB2ICAM1ITGALALDH1A1MAPT | |
| SCHEMBL5556226 | 0.78 | LMNA (0.41) | ITGB2ICAM1ITGALALDH1A1MAPT | |
| SCHEMBL5555513 | 0.78 | LRRK2 (0.35) | ITGB2ICAM1ITGALALDH1A1MAPT | |
| SCHEMBL5560808 | 0.76 | KCNA5 (0.37) | ALDH1A1MAPTLMNANPSR1TDP1 | |
| SCHEMBL5556007 | 0.76 | KMT2A (0.39) | ALDH1A1MAPTMEN1GAAKMT2A | |
| SCHEMBL5555512 | 0.76 | MAPT (0.42) | ALDH1A1MAPTKDM4EGAA | |
| SCHEMBL5556272 | 0.76 | ALDH1A1 (0.40) | ALDH1A1MAPTLMNANPSR1TDP1 | |
| SCHEMBL5561621 | 0.73 | MAPT (0.40) | ALDH1A1MAPTLMNATDP1KDM4E | |
| SCHEMBL5555802 | 0.72 | HCRTR1 (0.38) | ALDH1A1MAPTLMNAKDM4EMEN1 | |
| SCHEMBL5556335 | 0.71 | MDM2 (0.39) | ALDH1A1NPSR1TDP1KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1631296-B1 | 2,3,4,5-TETRAHYDROBENZO¬F|¬1,4|OXAZEPINE-5-CARBOXYLIC ACID AMIDE DERIVATIVES AS GAMMA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | HOFFMANN LA ROCHE (CH) | 2007-04-25 | — | — | EP | claimed |