Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | PTK2B | Q14289 | 2/20 | 0.49 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.49 |
| ▸ | GFER | P55789 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.49 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | CHKA | P35790 | 1/20 | 0.41 |
| ▸ | HTR3A | P46098 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1506928 | 0.84 | TRIM24 (0.53) | ALDH1A1MAPTKDM4EGAAPTK2B | |
| SCHEMBL6987741 | 0.83 | ALDH1A1 (0.55) | ALDH1A1MAPTKDM4EGAAGFER | |
| SCHEMBL27741268 | 0.81 | ALDH1A1 (0.59) | ALDH1A1MAPTKDM4EGAAPTK2B | |
| SCHEMBL21495008 | 0.81 | PIK3CD (0.46) | ALDH1A1MAPTKDM4EGAAKMT2A | |
| SCHEMBL3234322 | 0.81 | PIK3CD (0.46) | ALDH1A1MAPTKDM4EGAAKMT2A | |
| SCHEMBL14058868 | 0.80 | ADRB1 (0.49) | ALDH1A1KDM4ESIRT6LMNATP53 | |
| SCHEMBL6118334 | 0.77 | ALDH1A1 (0.46) | ALDH1A1KDM4EKMT2ARAB9ASMN1; SMN2 | |
| SCHEMBL4174461 | 0.76 | ALDH1A1 (0.53) | ALDH1A1MAPTKDM4EGAAPTK2B | |
| SCHEMBL14058852 | 0.76 | LMNA (0.53) | ALDH1A1KDM4ELMNANPC1RAB9A | |
| SCHEMBL14058888 | 0.75 | DRD4 (0.60) | ALDH1A1GAASIGMAR1HDAC3HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1628666-A4 | COMPOUDS AND USES THEREOF IN MODULATING AMYLOID BETA | TORREYPINES THERAPEUTICS INC (US) | 2007-12-05 | — | — | EP | disclosed |
| EP-1628666-A2 | COMPOUDS AND USES THEREOF IN MODULATING AMYLOID BETA | Torreypines Therapeutics, Inc. (US) | 2006-03-01 | — | — | EP | disclosed |
| WO-2004110350-A2 | COMPOUDS AND USES THEREOF IN MODULATING AMYLOID BETA | TORREYPINES THERAPEUTICS, INC. (US) | 2004-12-23 | — | — | WO | disclosed |