Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 8/20 | 0.60 |
| ▸ | RAB9A | P51151 | 8/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | PKM | P14618 | 2/20 | 0.55 |
| ▸ | TP53 | P04637 | 2/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.49 |
| ▸ | GRM5 | P41594 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.48 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.48 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2807153 | 0.75 | RAB9A (1.00) | NPC1RAB9ASMN1; SMN2CYP1A2PKM | |
| SCHEMBL4289654 | 0.75 | NPC1 (0.60) | NPC1RAB9ASMN1; SMN2CYP1A2PKM | |
| SCHEMBL9384187 | 0.73 | NPC1 (0.72) | NPC1RAB9ASMN1; SMN2CYP1A2PKM | |
| SCHEMBL28720941 | 0.73 | RAB9A (0.77) | NPC1RAB9ASMN1; SMN2CYP1A2PKM | |
| SCHEMBL5514972 | 0.73 | HPGD (0.70) | NPC1RAB9ASMN1; SMN2CYP1A2PKM | |
| SCHEMBL28713223 | 0.73 | HPGD (0.63) | NPC1RAB9ASMN1; SMN2CYP1A2PKM | |
| SCHEMBL997866 | 0.72 | RAB9A (0.89) | NPC1RAB9ASMN1; SMN2CYP1A2PKM | |
| SCHEMBL29366822 | 0.72 | RAB9A (0.89) | NPC1RAB9ASMN1; SMN2CYP1A2PKM | |
| SCHEMBL5011704 | 0.71 | RAB9A (0.86) | NPC1RAB9ASMN1; SMN2PKMTP53 | |
| SCHEMBL30565139 | 0.70 | RAB9A (1.00) | NPC1RAB9ASMN1; SMN2PKMMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE39591-E1 | 6-O-substituted ketolides having antibacterial activity | ABBOTT LABORATORIES (US) | 2007-04-24 | — | — | US | claimed |
| EP-0929563-A1 | 6-O-SUBSTITUTED KETOLIDES HAVING ANTIBACTERIAL ACTIVITY | Abbott Laboratories (US) | 1999-07-21 | — | — | EP | claimed |
| US-5866549-A | MACROLIDE ANTIBIOTICS | ABBOTT LABORATORIES (US) | 1999-02-02 | — | — | US | claimed |
| WO-1998009978-A1 | 6-O-SUBSTITUTED KETOLIDES HAVING ANTIBACTERIAL ACTIVITY | ABBOTT LABORATORIES (US) | 1998-03-12 | — | — | WO | claimed |
| CN-100460415-C | Ketolactones, their use and process for their preparation and pharmaceutical compositions containing them | ABBOTT LAB (US) | 2009-02-11 | — | — | CN | disclosed |
| CN-100441591-C | Ketolactones, their use and process for their preparation and pharmaceutical compositions containing them | ABBOTT LAB (US) | 2008-12-10 | — | — | CN | disclosed |
| US-RE39591-E1 | 6-O-substituted ketolides having antibacterial activity | ABBOTT LABORATORIES (US) | 2007-04-24 | — | — | US | disclosed |
| CN-1273475-C | 6-0-substituted ketolides with antibacterial activity | ABBOTT CO (US) | 2006-09-06 | — | — | CN | disclosed |
| EP-1291353-B1 | 6-O-substituted ketolides having antibacterial activity | ABBOTT LAB (US) | 2005-06-01 | — | — | EP | disclosed |
| EP-1291352-B1 | 6-O-substituted ketolides having antibacterial activity | ABBOTT LAB (US) | 2005-05-25 | — | — | EP | disclosed |
| EP-1291350-B1 | 6-0 substituted ketolides having antibacterial activity | ABBOTT LAB (US) | 2005-05-25 | — | — | EP | disclosed |
| EP-1291353-A1 | 6-O-substituted ketolides having antibacterial activity | ABBOTT LABORATORIES (US) | 2003-03-12 | — | — | EP | disclosed |
| EP-1291352-A1 | 6-O-substituted ketolides having antibacterial activity | ABBOTT LABORATORIES (US) | 2003-03-12 | — | — | EP | disclosed |
| US-6147197-A | INCREASED ACID STABILITY AND ENHANCED ACTIVITY TOWARD GRAM NEGATIVE BACTERIA AND MACROLIDE RESISTANT GRAM POSITIVE BACTERIA | ABBVIE INC. | 2000-11-14 | — | — | US | disclosed |
| US-6075133-A | INCREASED ACID STABILITY AND ENHANCED BACTERICIDAL ACTIVITY | ABBOTT LABORATORIES (US) | 2000-06-13 | — | — | US | disclosed |
| US-6028181-A | 6-0-Substituted antibacterial erythromycin ketolides and methods of making | ABBOTT LABORATORIES (US) | 2000-02-22 | — | — | US | disclosed |
| CN-1237183-A | 6-0-substituted ketolides with antibacterial activity | ABBOTT CO (US) | 1999-12-01 | — | — | CN | disclosed |
| EP-0929563-A1 | 6-O-SUBSTITUTED KETOLIDES HAVING ANTIBACTERIAL ACTIVITY | Abbott Laboratories (US) | 1999-07-21 | — | — | EP | disclosed |
| US-5866549-A | MACROLIDE ANTIBIOTICS | ABBOTT LABORATORIES (US) | 1999-02-02 | — | — | US | disclosed |
| WO-1998009978-A1 | 6-O-SUBSTITUTED KETOLIDES HAVING ANTIBACTERIAL ACTIVITY | ABBOTT LABORATORIES (US) | 1998-03-12 | — | — | WO | disclosed |