Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 18/20 | 0.41 |
| ▸ | MAP2K2 | P36507 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL392036 | 0.82 | MAP2K1 (0.45) | MAP2K1MAP2K2ALDH1A1L3MBTL1GAA | |
| SCHEMBL5559369 | 0.76 | MAP2K1 (0.44) | MAP2K1MAP2K2ALDH1A1L3MBTL1 | |
| SCHEMBL5031268 | 0.72 | MAP2K1 (0.42) | MAP2K1MAP2K2ALDH1A1L3MBTL1 | |
| SCHEMBL388765 | 0.72 | MAP2K1 (0.53) | MAP2K1MAP2K2 | |
| SCHEMBL391269 | 0.72 | MAP2K1 (0.48) | MAP2K1MAP2K2 | |
| SCHEMBL1775161 | 0.72 | MAP2K1 (0.45) | MAP2K1MAP2K2ALDH1A1GAAMAPT | |
| SCHEMBL5031270 | 0.71 | ALDH1A1 (0.41) | MAP2K1MAP2K2ALDH1A1L3MBTL1GAA | |
| SCHEMBL206342 | 0.71 | DGAT1 (0.59) | ALDH1A1L3MBTL1GAAMAPT | |
| SCHEMBL391260 | 0.71 | MAP2K1 (0.42) | MAP2K1MAP2K2 | |
| SCHEMBL388850 | 0.70 | MAP2K1 (0.51) | MAP2K1MAP2K2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1682138-A4 | HETEROCYCLIC INHIBITORS OF MEK AND METHODS OF USE THEREOF | ARRAY BIOPHARMA INC (US) | 2007-01-24 | — | — | EP | disclosed |
| EP-1682138-A2 | HETEROCYCLIC INHIBITORS OF MEK AND METHODS OF USE THEREOF | Array Biopharma, Inc. (US) | 2006-07-26 | — | — | EP | disclosed |
| WO-2005051301-A2 | HETEROCYCLIC INHIBITORS OF MEK AND METHODS OF USE THEREOF | ARRAY BIOPHARMA INC. (US) | 2005-06-09 | — | — | WO | disclosed |