Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | FPR2 | P25090 | 2/20 | 0.40 |
| ▸ | MAP2K1 | Q02750 | 8/20 | 0.39 |
| ▸ | MAP2K2 | P36507 | 2/20 | 0.39 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.39 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5560575 | 0.87 | MAP2K1 (0.43) | ALDH1A1L3MBTL1MAPTFPR2MAP2K1 | |
| SCHEMBL392036 | 0.81 | MAP2K1 (0.45) | ALDH1A1L3MBTL1GAAMAP2K1MAP2K2 | |
| SCHEMBL206342 | 0.72 | DGAT1 (0.59) | ALDH1A1L3MBTL1GAAMAPTDGAT1 | |
| SCHEMBL5559374 | 0.71 | MAP2K1 (0.41) | ALDH1A1L3MBTL1GAAMAPTTDP1 | |
| SCHEMBL26615720 | 0.70 | CHEK1 (0.49) | ALDH1A1GAAMAPTTDP1KMT2A | |
| Iodomethane SCHEMBL5739657 | 0.70 | DGAT1 (0.56) | ALDH1A1L3MBTL1GAAMAPTDGAT1 | |
| SCHEMBL388633 | 0.69 | MAP2K1 (0.52) | ALDH1A1MAPTFPR2MAP2K1MAP2K2 | |
| SCHEMBL5031268 | 0.69 | MAP2K1 (0.42) | ALDH1A1L3MBTL1MAP2K1MAP2K2KMT2A | |
| SCHEMBL2365705 | 0.69 | CHEK1 (0.48) | ALDH1A1GAAMAPTKMT2A | |
| SCHEMBL924959 | 0.68 | CHEK1 (0.47) | ALDH1A1GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1922307-A2 | HETEROCYCLIC INHIBITORS OF MEK AND METHODS OF USE THEREOF | Array Biopharma, Inc. (US) | 2008-05-21 | — | — | EP | disclosed |
| WO-2007044084-A2 | HETEROCYCLIC INHIBITORS OF MEK AND METHODS OF USE THEREOF | ARRAY BIOPHARMA INC. (US) | 2007-04-19 | — | — | WO | disclosed |