Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 4/20 | 0.76 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.76 |
| ▸ | AKR1C3 | P42330 | 10/20 | 0.64 |
| ▸ | AKR1C2 | P52895 | 10/20 | 0.64 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.56 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.56 |
| ▸ | AKR1C4 | P17516 | 2/20 | 0.56 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | PTGES | O14684 | 1/20 | 0.56 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.56 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.56 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.56 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5554419 | 0.90 | PTGS1 (0.74) | PTGS1PTGS2AKR1C3AKR1C2ABCB1 | |
| SCHEMBL6423975 | 0.90 | PTGS2 (0.61) | PTGS1PTGS2AKR1C3AKR1C2ABCB1 | |
| SCHEMBL6461262 | 0.89 | PTGS2 (0.60) | PTGS1PTGS2AKR1C3AKR1C2ABCB1 | |
| SCHEMBL2997297 | 0.88 | PTGS2 (0.79) | PTGS1PTGS2AKR1C3AKR1C2ABCB1 | |
| SCHEMBL6423281 | 0.88 | PTGS2 (0.59) | PTGS1PTGS2AKR1C3AKR1C2NPSR1 | |
| SCHEMBL5554196 | 0.87 | PTGS2 (0.62) | PTGS1PTGS2AKR1C3AKR1C2 | |
| SCHEMBL5800688 | 0.86 | PTGS2 (0.56) | PTGS1PTGS2AKR1C3AKR1C2ABCB1 | |
| SCHEMBL5559379 | 0.86 | AKR1C3 (0.58) | PTGS1PTGS2AKR1C3AKR1C2ABCB1 | |
| SCHEMBL5561882 | 0.86 | PTGS2 (0.61) | PTGS1PTGS2AKR1C3AKR1C2 | |
| SCHEMBL2996680 | 0.86 | PTGS1 (1.00) | PTGS1PTGS2AKR1C3AKR1C2ABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1628532-A2 | METHODS FOR THE PROTECTION OF MEMORY AND COGNITION | Microbia, Inc. (US) | 2006-03-01 | — | — | EP | claimed |
| US-20050004104-A1 | Methods for the protection of memory and cognition | IRONWOOD PHARMACEUTICALS, INC. | 2005-01-06 | — | — | US | claimed |
| WO-2004108085-A2 | METHODS FOR THE PROTECTION OF MEMORY AND COGNITION | MICROBIA, INC. (US) | 2004-12-16 | — | — | WO | claimed |
| US-20070293542-A1 | Selective Cox-2 Inhibitors | IRONWOOD PHARMACEUTICALS, INC. | 2007-12-20 | — | — | US | disclosed |
| US-20070293542-A1 | Selective Cox-2 Inhibitors | IRONWOOD PHARMACEUTICALS, INC. | 2007-12-20 | — | — | US | disclosed |
| EP-1643961-A4 | COX-2 AND FAAH INHIBITORS | MICROBIA INC (US) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006050120-A2 | SYNTHESIS OF COX-2 AND FAAH INHIBITORS | MICROBIA, INC. (US) | 2006-05-11 | — | — | WO | disclosed |
| EP-1643961-A2 | COX-2 AND FAAH INHIBITORS | Microbia, Inc. (US) | 2006-04-12 | — | — | EP | disclosed |
| EP-1628532-A2 | METHODS FOR THE PROTECTION OF MEMORY AND COGNITION | Microbia, Inc. (US) | 2006-03-01 | — | — | EP | disclosed |
| US-20050234244-A1 | Synthesis of COX-2 and FAAH inhibitors | IRONWOOD PHARMACEUTICALS, INC. | 2005-10-20 | — | — | US | disclosed |
| US-20050032747-A1 | COX-2 and FAAH inhibitors | POLYMER CONCEPTS TECHNOLOGIES PBY, INC. | 2005-02-10 | — | — | US | disclosed |
| WO-2005002525-A2 | COX-2 AND FAAH INHIBITORS | MICROBIA, INC. (US) | 2005-01-13 | — | — | WO | disclosed |
| US-20050004104-A1 | Methods for the protection of memory and cognition | IRONWOOD PHARMACEUTICALS, INC. | 2005-01-06 | — | — | US | disclosed |
| WO-2004108085-A2 | METHODS FOR THE PROTECTION OF MEMORY AND COGNITION | MICROBIA, INC. (US) | 2004-12-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070293542-A1 | Selective Cox-2 Inhibitors | PTGS2, FAAH2, PTGES2 | PTGS1 7/4885PTGS2 1/4885AKR1C3 1000/4885 |
| US-20050004104-A1 | Methods for the protection of memory and cognition | PTGES2, PTGS2, PTGS1 | PTGS1 3/4885PTGS2 2/4885AKR1C3 2613/4885 |
| US-20050032747-A1 | COX-2 and FAAH inhibitors | FAAH2, FAAH, PTGS2 | PTGS1 6/4885PTGS2 3/4885AKR1C3 585/4885 |
| US-20050234244-A1 | Synthesis of COX-2 and FAAH inhibitors | FAAH2, FAAH, PTGES2 | PTGS1 7/4885PTGS2 4/4885AKR1C3 577/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.