Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 6/20 | 0.62 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.33 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.33 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.33 |
| ▸ | YAP1 | P46937 | 1/20 | 0.33 |
| ▸ | GHSR | Q92847 | 1/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.32 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.32 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.32 |
| ▸ | TACR1 | P25103 | 1/20 | 0.32 |
| ▸ | TPSAB1 | Q15661 | 2/20 | 0.32 |
| ▸ | TPSD1 | Q9BZJ3 | 2/20 | 0.32 |
| ▸ | TPSG1 | Q9NRR2 | 2/20 | 0.32 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL557670 | 0.95 | REN (0.64) | RENKCNH2CYP3A4YAP1GPR119 | |
| SCHEMBL556433 | 0.94 | REN (0.60) | RENKCNH2CYP3A4YAP1GHSR | |
| SCHEMBL556610 | 0.92 | REN (0.64) | RENKCNH2CYP3A4YAP1TACR1 | |
| SCHEMBL557191 | 0.92 | REN (0.63) | RENKCNH2CYP3A4YAP1GPR119 | |
| SCHEMBL556555 | 0.90 | REN (0.59) | RENKCNH2CYP3A4GPR119TACR1 | |
| SCHEMBL556596 | 0.85 | REN (0.54) | RENKCNH2CYP3A4TACR1ALK | |
| SCHEMBL556138 | 0.83 | REN (0.58) | RENKCNH2CYP3A4GHSR | |
| SCHEMBL556537 | 0.83 | KCNH2 (0.72) | RENKCNH2CYP3A4GPR119TACR1 | |
| SCHEMBL557671 | 0.79 | REN (0.60) | RENKCNH2CYP3A4GHSR | |
| SCHEMBL10202784 | 0.79 | REN (0.90) | RENKCNH2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120035214-A1 | RENIN INHIBITORS | MERCK CANADA INC. (CA) | 2012-02-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120035214-A1 | RENIN INHIBITORS | REN, ACE, AGTR1 | REN 1/4885KCNH2 1198/4885CYP3A4 766/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.